Western Blot (WB)
(WB Suggested Anti-MDS1 Antibody Titration: 1.25ug/mlELISA Titer: 1:312500Positive Control: Raji cell lysate)
Rabbit MDS1 Polyclonal Antibody | anti-MDS1 antibody
MDS1 antibody - N-terminal region
Western Blot (WB)
(WB Suggested Anti-MDS1 Antibody Titration: 1.25ug/mlELISA Titer: 1:312500Positive Control: Raji cell lysate)
Western Blot (WB)
(WB Suggested Anti-MDS1 Antibody Titration: 1.25ug/mlELISA Titer: 1:312500Positive Control: Raji cell lysate)
Target Description: MDS1 is located at 3q26 170-400 kb upstream (telomeric) of EVI1 in the chromosomal region in which some of the breakpoints 5' of EVI1 have been mapped. MDS1 has been identified as a single gene as well as a previously unreported exon(s) of EVI1. MDS1 exists in normal tissues both as a unique transcript and as a normal fusion transcript with EVI1, with an additional 188 codons at the 5' end of the previously reported EVI1 open reading frame. In cells with translocation t (3;21), additional fusion transcripts are AML1-MDS1 and AML1-MDS1-EVI1. EVI1 and MDS1 are involved in leukemia associated with chromosomal translocation breakpoints in the region between these genes.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Uniprot Description
MDS1: A chromosomal aberration involving MDS1 is found in a form of acute myeloid leukemia (AML). Translocation t(3;21) with AML1. 6 isoforms of the human protein are produced by alternative promoter.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 3q26.2
Cellular Component: nucleoplasm; Golgi apparatus; intracellular membrane-bound organelle; cytoplasm; histone deacetylase complex; nuclear speck; nucleus
Molecular Function: protein binding; protein homodimerization activity; DNA binding; metal ion binding; transcription factor activity
Biological Process: embryonic forelimb morphogenesis; pericardium development; negative regulation of JNK cascade; transcription, DNA-dependent; in utero embryonic development; regulation of cell cycle; apoptosis; positive regulation of transcription, DNA-dependent; neutrophil homeostasis; embryonic hindlimb morphogenesis; regulation of cell proliferation; post-embryonic development; regulation of transcription, DNA-dependent; response to bacterium; forebrain development; negative regulation of programmed cell death; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; cell differentiation; inflammatory response; negative regulation of transforming growth factor beta receptor signaling pathway
Research Articles on MDS1
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Product Notes
The MDS1 mecom (Catalog #AAA3204133) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MDS1 antibody - N-terminal region reacts with Human, Mouse, Zebrafish and may cross-react with other species as described in the data sheet. AAA Biotech's MDS1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the MDS1 mecom for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: MRSKGRARKL ATNNECVYGN YPEIPLEEMP DADGVASTPS LNIQEPCSPA. It is sometimes possible for the material contained within the vial of "MDS1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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