Western Blot (WB)
(Western blot analysis of MD-1 in Daudi cell lysate with MD-1 antibody at (A) 1 and (B) 2 ug/mL.)
Rabbit MD-1 Polyclonal Antibody | anti-MD-1 antibody
MD-1 Antibody
Gene Names
LY86; MD1; MD-1; MMD-1; dJ80N2.1
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot, Immunohistochemistry
Purity
Affinity chromatography purified via peptide column
Synonyms
MD-1; Polyclonal Antibody; MD-1 Antibody; Lymphocyte antigen 86; anti-MD-1 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
162
Applicable Applications for anti-MD-1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Immunogen Type
Peptide
Immunogen Description
Raised against a 15 amino acid peptide from near the center of human MD-1.
Target Name
MD-1
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Western Blot (WB)
(Western blot analysis of MD-1 in Daudi cell lysate with MD-1 antibody at (A) 1 and (B) 2 ug/mL.)
Western Blot (WB)
(Western blot analysis of MD-1 in Daudi cell lysate with MD-1 antibody at (A) 1 and (B) 2 ug/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of MD-1 in human spleen tissue with MD-1 antibody at 2.5 ug/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of MD-1 in human spleen tissue with MD-1 antibody at 2.5 ug/mL.)
Related Product Information for anti-MD-1 antibody
Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The signaling of these TLRs is kept under tight control by the expression of endogenous inhibiting proteins such as RP105, a recently identified homolog of TLR4. This protein, in association with MD-1, interacts with and inhibits the TLR4/MD-2 signaling pathway. While MD-2 can directly bind to LPS, one of the activating molecules of TLR4, the function of MD-1 is less well-known. It has been suggested however, that the RP105/MD-1 complex influences antibody production mediated by both TLR4/MD-2 and TLR2 receptor complexes.
Product Categories/Family for anti-MD-1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
17,906 Da
NCBI Official Full Name
lymphocyte antigen 86
NCBI Official Synonym Full Names
lymphocyte antigen 86
NCBI Official Symbol
LY86
NCBI Official Synonym Symbols
MD1; MD-1; MMD-1; dJ80N2.1
NCBI Protein Information
lymphocyte antigen 86
UniProt Protein Name
Lymphocyte antigen 86
UniProt Gene Name
LY86
UniProt Synonym Gene Names
MD1; Ly-86
UniProt Entry Name
LY86_HUMAN
Uniprot Description
LY86: May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression.
Protein type: Secreted; Apoptosis; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 6p25.1
Cellular Component: extracellular space; plasma membrane
Biological Process: cell proliferation; apoptosis; positive regulation of lipopolysaccharide-mediated signaling pathway; innate immune response; inflammatory response; humoral immune response
Research Articles on MD-1
1. DNA methylation of the LY86 gene is associated with obesity, insulin resistance, and inflammation.
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Product Notes
The MD-1 ly86 (Catalog #AAA9412281) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MD-1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's MD-1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the MD-1 ly86 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MD-1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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