Western Blot (WB)
(Western Blot analysis of MCM6 expression in transfected 293T cell line by MCM6 MaxPab polyclonal antibody.Lane 1: MCM6 transfected lysate(92.9 KDa).Lane 2: Non-transfected lysate.)
Rabbit anti-Human MCM6 Polyclonal Antibody | anti-MCM6 antibody
MCM6 (Minichromosome Maintenance Complex Component 6, MCG40308, Mis5, P105MCM) (PE)
Western Blot (WB)
(Western Blot analysis of MCM6 expression in transfected 293T cell line by MCM6 MaxPab polyclonal antibody.Lane 1: MCM6 transfected lysate(92.9 KDa).Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of MCM6 expression in transfected 293T cell line by MCM6 MaxPab polyclonal antibody.Lane 1: MCM6 transfected lysate(92.9 KDa).Lane 2: Non-transfected lysate.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood. [provided by RefSeq, May 2012]
Uniprot Description
MCM6: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Belongs to the MCM family.
Protein type: EC 3.6.4.12; Cell cycle regulation
Chromosomal Location of Human Ortholog: 2q21
Cellular Component: nucleoplasm; MCM complex; nucleus
Molecular Function: ATP-dependent DNA helicase activity; identical protein binding; protein binding; single-stranded DNA binding; ATP binding
Biological Process: DNA unwinding during replication; DNA replication initiation; mitotic cell cycle; DNA strand elongation during DNA replication; DNA replication; G1/S transition of mitotic cell cycle
Disease: Lactose Intolerance, Adult Type
Research Articles on MCM6
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Product Notes
The MCM6 mcm6 (Catalog #AAA6451233) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MCM6 (Minichromosome Maintenance Complex Component 6, MCG40308, Mis5, P105MCM) (PE) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MCM6 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the MCM6 mcm6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MCM6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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