Rabbit anti-Human MC2R Polyclonal Antibody | anti-MC2R antibody

MC2R (Melanocortin 2 Receptor, ACTHR) (Biotin)

Cat. Num. AAA6426223

• Gene Names: MC2R; ACTHR
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by affinity chromatography.
• Synonyms: MC2R; Polyclonal Antibody; MC2R (Melanocortin 2 Receptor; ACTHR) (Biotin); anti-MC2R antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human MC2R.
• Purity/Purification: Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
• Concentration: ~1mg/ml (varies by lot)

• Applicable Applications for anti-MC2R antibody: Western Blot (WB)
• Application Notes: WB: 1:1000-1:2000; Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide corresponding to human MC2R.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of extracts of 293 cell lysate, using MC2R antibody.)

Product Categories/Family for anti-MC2R antibody

Antibodies; Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 4505127
• NCBI GeneID: 4158
• NCBI Accession #: NP_000520.1
• NCBI GenBank Nucleotide #: NM_000529.2
• UniProt Accession #: Q01718; Q3MI45; Q504X6; A8K016
• Molecular Weight: 33,927 Da
• NCBI Official Full Name: adrenocorticotropic hormone receptor
• NCBI Official Synonym Full Names: melanocortin 2 receptor (adrenocorticotropic hormone)
• NCBI Official Symbol: MC2R
• NCBI Official Synonym Symbols: ACTHR
• NCBI Protein Information: adrenocorticotropic hormone receptor; MC2 receptor; ACTH receptor; corticotropin receptor; adrenocorticotropin receptor
• UniProt Protein Name: Adrenocorticotropic hormone receptor
• Protein Family: Adrenocorticotropic hormone receptor
• UniProt Gene Name: MC2R
• UniProt Synonym Gene Names: ACTHR; ACTH receptor; ACTH-R; MC2-R
• UniProt Entry Name: ACTHR_HUMAN

NCBI Description

MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. [provided by RefSeq, Jul 2008]

Uniprot Description

MC2R: Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase. Defects in MC2R are the cause of glucocorticoid deficiency type 1 (GCCD1); also known as familial glucocorticoid deficiency type 1 (FGD1). GCCD1 is an autosomal recessive disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 18p11.2

Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane

Molecular Function: protein binding; melanocortin receptor activity; adrenocorticotropin receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; neuropeptide signaling pathway; positive regulation of cAMP biosynthetic process; placenta development

Disease: Glucocorticoid Deficiency 1