Rabbit anti-Human MATR3 Polyclonal Antibody | anti-MATR3 antibody

MATR3, NT (MATR3, KIAA0723, Matrin-3)

Cat. Num. AAA6001602

• Gene Names: MATR3; MPD2; VCPDM
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: MATR3; Polyclonal Antibody; NT (MATR3; KIAA0723; Matrin-3); Anti -MATR3; anti-MATR3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-MATR3 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: MATR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-186 amino acids from the N-terminal region of human MATR3.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(MATR3 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the MATR3 antibody detected the MATR3 protein (arrow).)

Related Product Information for anti-MATR3 antibody

This locus encodes a nuclear matrix protein. Mutations at this locus have been associated with distal myopathy 2, which often includes vocal cord and pharyngeal weakness. Alternatively spliced transcript variants, including read-through transcripts with an upstream locus have been described. Related pseuodgenses have been defined on chr1 and chrX.

Product Categories/Family for anti-MATR3 antibody

Antibodies; Abs to KIAA; orf

NCBI and Uniprot Product Information

• NCBI GI #: 533112484
• NCBI GeneID: 9782
• NCBI Accession #: NP_001269207.1
• NCBI GenBank Nucleotide #: NM_001282278.1
• UniProt Accession #: P43243; Q9UHW0; Q9UQ27; B7ZAV5; D3DQC3
• Molecular Weight: 94,623 Da
• NCBI Official Full Name: matrin-3 isoform c
• NCBI Official Synonym Full Names: matrin 3
• NCBI Official Symbol: MATR3
• NCBI Official Synonym Symbols: MPD2; VCPDM
• NCBI Protein Information: matrin-3; vocal cord and pharyngeal weakness with distal myopathy
• UniProt Protein Name: Matrin-3
• Protein Family: Matrin
• UniProt Gene Name: MATR3
• UniProt Synonym Gene Names: KIAA0723
• UniProt Entry Name: MATR3_HUMAN

NCBI Description

This gene encodes a nuclear matrix protein, which is proposed to stabilize certain messenger RNA species. Mutations of this gene are associated with distal myopathy 2, which often includes vocal cord and pharyngeal weakness. Alternatively spliced transcript variants, including read-through transcripts composed of the upstream small nucleolar RNA host gene 4 (non-protein coding) and matrin 3 gene sequence, have been identified. Pseudogenes of this gene are located on chromosomes 1 and X. [provided by RefSeq, Aug 2013]

Uniprot Description

matrin 3: an acidic protein that is a component of the nuclear matrix. May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network.

Protein type: RNA processing; RNA-binding

Chromosomal Location of Human Ortholog: 5q31.2

Cellular Component: nucleoplasm; nuclear matrix; membrane; nuclear inner membrane

Molecular Function: protein binding; zinc ion binding; nucleotide binding; structural molecule activity

Disease: Amyotrophic Lateral Sclerosis 21