Rabbit MASP1 HC Polyclonal Antibody | anti-MASP1 antibody

Anti-MASP1 HC Antibody

Cat. Num. AAA821957

• Gene Names: MASP1; 3MC1; MAP1; MASP; RaRF; CRARF; MASP3; MAp44; PRSS5; CRARF1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was purified by immunogen affinity chromatography.
• Synonyms: MASP1 HC; Polyclonal Antibody; Anti-MASP1 HC Antibody; CRARF; CRARF1; PRSS5; Mannan-binding lectin serine protease 1; Complement factor MASP-3; Complement-activating component of Ra-reactive factor; Mannose-binding lectin-associated serine protease 1; MASP-1; Mannose-binding protein-associated serine protease; Ra-reactive factor serine protease p100; RaRF; Serine protease 5; anti-MASP1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: Recognizes endogenous levels of MASP1 HC protein.
• Purity/Purification: The antibody was purified by immunogen affinity chromatography.
• Form/Format: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
• Sequence Length: 380

• Applicable Applications for anti-MASP1 antibody: Western Blot (WB)
• Application Notes: WB (1/500 - 1/1000)
• Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human MASP1 HC. The exact sequence is proprietary.
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of MASP1 HC expression in A549 colchicine-treated (A), mouse lung (B), rat liver (C) whole cell lysates.)

Related Product Information for anti-MASP1 antibody

Rabbit polyclonal antibody to MASP1 HC

NCBI and Uniprot Product Information

• NCBI GI #: 73623026
• NCBI GeneID: 5648
• NCBI Accession #: NP_001027019.1
• NCBI GenBank Nucleotide #: NM_001031849.2
• UniProt Accession #: P48740; O95570; Q68D21; Q8IUV8; Q96RS4; Q9UF09; A8K542; A8K6M1; B4E2L7
• Molecular Weight: 68,918 Da
• NCBI Official Full Name: mannan-binding lectin serine protease 1 isoform 3
• NCBI Official Synonym Full Names: mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
• NCBI Official Symbol: MASP1
• NCBI Official Synonym Symbols: 3MC1; MAP1; MASP; RaRF; CRARF; MASP3; MAp44; PRSS5; CRARF1
• NCBI Protein Information: mannan-binding lectin serine protease 1; serine protease 5; complement factor MASP-3; Ra-reactive factor serine protease p100; mannose-binding protein-associated serine protease; mannose-binding lectin-associated serine protease 1; complement-activating component of Ra-reactive factor
• UniProt Protein Name: Mannan-binding lectin serine protease 1
• Protein Family: Mannan-binding lectin serine protease
• UniProt Gene Name: MASP1
• UniProt Synonym Gene Names: CRARF; CRARF1; PRSS5; MASP-1; RaRF
• UniProt Entry Name: MASP1_HUMAN

NCBI Description

This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]

Uniprot Description

MASP1: Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Defects in MASP1 are the cause of 3MC syndrome type 1 (3MC1). 3MC1 is a disorder characterized by facial dysmorphism that includes hypertelorism, blepharophimosis, blepharoptosis and highly arched eyebrows, cleft lip and/or palate, craniosynostosis, learning disability and genital, limb and vesicorenal anomalies. The term 3MC syndrome includes Carnevale, Mingarelli, Malpuech, and Michels syndromes. Belongs to the peptidase S1 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; EC 3.4.21.-; Protease; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3q27-q28

Cellular Component: extracellular space; extracellular region

Molecular Function: peptidase activity; protein binding; protein homodimerization activity; serine-type endopeptidase activity; calcium ion binding; calcium-dependent protein binding

Biological Process: receptor-mediated endocytosis; negative regulation of complement activation; innate immune response; complement activation, lectin pathway; proteolysis; complement activation

Disease: 3mc Syndrome 1