Rabbit anti-Human MAPRE2 Polyclonal Antibody | anti-MAPRE2 antibody

MAPRE2, NT (MAPRE2, RP1, Microtubule-associated protein RP/EB family member 2, APC-binding protein EB2, End-binding protein 2) (Azide free) (HRP)

Cat. Num. AAA6318917

• Gene Names: MAPRE2; EB1; EB2; RP1; CSCSC2
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: MAPRE2; Polyclonal Antibody; NT (MAPRE2; RP1; Microtubule-associated protein RP/EB family member 2; APC-binding protein EB2; End-binding protein 2) (Azide free) (HRP); End-binding protein 2; anti-MAPRE2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
• Sequence Length: 315

• Applicable Applications for anti-MAPRE2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: MAPRE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-40 amino acids from the N-terminal region of human MAPRE2.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(MAPRE2 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the MAPRE2 antibody detected the MAPRE2 protein (arrow).)

Related Product Information for anti-MAPRE2 antibody

The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. The function of this protein is unknown; however, its homology suggests involvement in tumorigenesis of colorectal cancers and proliferative control of normal cells. This gene may belong to the intermediate/early gene family, involved in the signal transduction cascade downstream of the TCR. Alternative splicing results in multiple transcript variants. [provided by RefSeq].

Product Categories/Family for anti-MAPRE2 antibody

Antibodies; Binding Proteins

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): De Groot, C.O., et al. J. Biol. Chem. 285(8):5802-5814(2010). Zhu, Z.C., et al. J. Biol. Chem. 284(47):32651-32661(2009). Abiatari, I., et al. Int. J. Oncol. 35(5):1111-1116(2009). Manna, T., et al. Biochemistry 47(2):779-786(2008).

NCBI and Uniprot Product Information

• NCBI GI #: 219842327
• NCBI GeneID: 10982
• NCBI Accession #: NP_001137299.1; NP_055083.1; NP_001137298.1
• NCBI GenBank Nucleotide #: NP_001137299.1
• UniProt Accession #: Q15555
• NCBI Official Full Name: microtubule-associated protein RP/EB family member 2 isoform 3
• NCBI Official Synonym Full Names: microtubule associated protein RP/EB family member 2
• NCBI Official Symbol: MAPRE2
• NCBI Official Synonym Symbols: EB1; EB2; RP1; CSCSC2
• NCBI Protein Information: microtubule-associated protein RP/EB family member 2
• UniProt Protein Name: Microtubule-associated protein RP/EB family member 2
• Protein Family: Microtubule-associated protein RP/EB family
• UniProt Gene Name: MAPRE2
• UniProt Synonym Gene Names: RP1; EB2
• UniProt Entry Name: MARE2_HUMAN

NCBI Description

The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle symmetry during mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Uniprot Description

RP1: shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. Its function is unknown; however, its homology suggests involvement in tumorigenesis of colorectal cancers and proliferative control of normal cells. This gene may belong to the intermediate/early gene family, involved in the signal transduction cascade downstream of the TCR.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 18q12.1

Cellular Component: microtubule cytoskeleton; cytoplasm

Molecular Function: microtubule binding

Biological Process: cell proliferation; mitosis; cell division; signal transduction