Rabbit MAP3K14 Polyclonal Antibody | anti-MAP3K14 antibody

MAP3K14 Antibody BIOTIN-Conjugated

Cat. Num. AAA542034

• Gene Names: MAP3K14; HS; NIK; HSNIK; FTDCR1B
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Synonyms: MAP3K14; Polyclonal Antibody; MAP3K14 Antibody BIOTIN-Conjugated; FTDCR1B; HS; HsNIK; Mitogen activated protein kinase kinase kinase 14; NF kappa beta inducing kinase; NIK; Serine/threonine-protein kinase NIK antibody; anti-MAP3K14 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Form/Format: BIOTIN-Conjugated
• Concentration: 0.64-0.72 ug/ul in antibody stabilization buffer (varies by lot)
• Sequence Length: 947

• Applicable Applications for anti-MAP3K14 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: Dot Blot: 1:10,000; ELISA: 1:10,000; Western Blot: 1:500
• Immunogen: Synthetic peptide taken within amino acid region 250-350 on human MAP3K14 protein.
• Expression: Weakly expressed in testis, small intestine, spleen, thymus, peripheral blood leukocytes, prostate, ovary and colon.
• Molecular Function: Kinase, Serine/threonine-protein kinase, Transferase
• Structure: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
• Subcellular Location: Cytoplasm
• Preparation and Storage: -20 degree C for long term storage

Related Product Information for anti-MAP3K14 antibody

BIOTIN-Conjugated Mitogen-activated protein kinase kinase kinase 14 Antibody
Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity.

NCBI and Uniprot Product Information

• NCBI GI #: 92090612
• NCBI GeneID: 9020
• UniProt Accession #: Q99558; Q8IYN1; A8K2D8; D3DX67
• Molecular Weight: 104,042 Da
• NCBI Official Full Name: Mitogen-activated protein kinase kinase kinase 14
• NCBI Official Synonym Full Names: mitogen-activated protein kinase kinase kinase 14
• NCBI Official Symbol: MAP3K14
• NCBI Official Synonym Symbols: HS; NIK; HSNIK; FTDCR1B
• NCBI Protein Information: mitogen-activated protein kinase kinase kinase 14
• UniProt Protein Name: Mitogen-activated protein kinase kinase kinase 14
• Protein Family: Mitogen-activated protein kinase kinase kinase
• UniProt Gene Name: MAP3K14
• UniProt Synonym Gene Names: NIK; HsNIK
• UniProt Entry Name: M3K14_HUMAN

NCBI Description

This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]

Uniprot Description

Nik: a protein kinase of the STE group of kinases. Binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.

Protein type: EC 2.7.11.25; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; STE group; STE-Unique family

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: cytoplasm; cytosol

Molecular Function: ATP binding; kinase activity; MAP kinase kinase kinase activity; NF-kappaB-inducing kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: activation of MAPKK activity; I-kappaB kinase/NF-kappaB cascade; immune response; MAPKKK cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; T cell costimulation; tumor necrosis factor-mediated signaling pathway