Immunohistochemistry (IHC)
(Anti-Mannose 6 Phosphate Receptor(Cation independent) antibody, MBS177024, IHC(P)IHC(P): Human Intestinal Cancer Tissue )
Rabbit Mannose 6 Phosphate Receptor(Cation independent) Polyclonal Antibody | anti-IGF2R antibody
Anti-Mannose 6 Phosphate Receptor(Cation independent) antibody
Immunohistochemistry (IHC)
(Anti-Mannose 6 Phosphate Receptor(Cation independent) antibody, MBS177024, IHC(P)IHC(P): Human Intestinal Cancer Tissue )
Immunohistochemistry (IHC)
(Anti-Mannose 6 Phosphate Receptor(Cation independent) antibody, MBS177024, IHC(P)IHC(P): Human Intestinal Cancer Tissue )
Immunocytochemistry (ICC)
(Anti-Mannose 6 Phosphate Receptor(Cation independent) antibody, MBS177024, ICCICC: HCT116 Cell )
Immunocytochemistry (ICC)
(Anti-Mannose 6 Phosphate Receptor(Cation independent) antibody, MBS177024, ICCICC: HCT116 Cell )
Western Blot (WB)
(Anti-Mannose 6 Phosphate Receptor(Cation independent) antibody, Western blottingAll lanes: Anti Mannose 6 Phosphate Receptor (Cation independent) (MBS177024) at 0.5ug/mlLane 1: HELA Whole Cell Lysate at 40ugLane 2: JURKAT Whole Cell Lysate at 40ugLane 3: 22RV1 Whole Cell Lysate at 40ugLane 4: 293T Whole Cell Lysate at 40ugPredicted bind size: 274KDObserved bind size: 274KD )
Western Blot (WB)
(Anti-Mannose 6 Phosphate Receptor(Cation independent) antibody, Western blottingAll lanes: Anti Mannose 6 Phosphate Receptor (Cation independent) (MBS177024) at 0.5ug/mlLane 1: HELA Whole Cell Lysate at 40ugLane 2: JURKAT Whole Cell Lysate at 40ugLane 3: 22RV1 Whole Cell Lysate at 40ugLane 4: 293T Whole Cell Lysate at 40ugPredicted bind size: 274KDObserved bind size: 274KD )
Background: Insulin-like growth factor 2 receptor, also called IGF2R or I-MPR is a protein that in humans is encoded by the IGF2R gene. This gene is mapped to 6q25.3. This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate, although the binding sites for either are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. While the related mouse gene shows exclusive expression from the maternal allele, imprinting of the human gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate, although the binding sites for either are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. While the related mouse gene shows exclusive expression from the maternal allele, imprinting of the human gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele. [provided by RefSeq, Apr 2013]
Uniprot Description
IGF2R: a multifunctional type I transmembrane protein receptor that binds insulin-like growth factor 2 at the cell surface and mannose-6-phosphate-tagged proteins in the trans-Golgi network. Also known as the cation-independent mannose-6 phosphate (M6P) receptor. Clears IGF2 from the cell surface to attenuate signaling, and transports M6P-tagged lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. M6P-tagged lysosomal enzymes bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Belongs to the MRL1/IGF2R family.
Protein type: Vesicle; Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 6q26
Cellular Component: extracellular space; cell surface; clathrin coat; focal adhesion; integral to plasma membrane; lysosomal membrane; trans-Golgi network; trans-Golgi network transport vesicle; membrane; endocytic vesicle; perinuclear region of cytoplasm; nuclear envelope lumen; late endosome; endosome
Molecular Function: G-protein coupled receptor activity; mannose binding; identical protein binding; protein binding; enzyme binding; retinoic acid binding; transporter activity; G-protein alpha-subunit binding; phosphoprotein binding; receptor activity; glycoprotein binding; insulin-like growth factor II binding; insulin-like growth factor receptor activity
Biological Process: receptor-mediated endocytosis; G-protein coupled receptor protein signaling pathway; organ regeneration; response to retinoic acid; insulin-like growth factor receptor signaling pathway; positive regulation of apoptosis; spermatogenesis; signal transduction; liver development; post-embryonic development
Disease: Hepatocellular Carcinoma
Research Articles on IGF2R
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Product Notes
The IGF2R igf2r (Catalog #AAA177024) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Mannose 6 Phosphate Receptor(Cation independent) antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Mannose 6 Phosphate Receptor(Cation independent) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC). Researchers should empirically determine the suitability of the IGF2R igf2r for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Mannose 6 Phosphate Receptor(Cation independent), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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