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Western Blot (WB) (Western Blot analysis of extracts of Mouse kidney cell line, using M6PR antibody.)

Rabbit anti-Human, Mouse M6PR Polyclonal Antibody | anti-M6PR antibody

M6PR Polyclonal Antibody

Gene Names
M6PR; SMPR; MPR46; CD-MPR; MPR 46; MPR-46; CD-M6PR
Reactivity
Human, Mouse
Applications
Western Blot, Immunohistochemistry
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Synonyms
M6PR; Polyclonal Antibody; M6PR Polyclonal Antibody; Cation-dependent mannose-6-phosphate receptor; CD Man-6-P receptor; CD-MPR; 46 kDa mannose 6-phosphate receptor; MPR 46; MPR46; MPRD; anti-M6PR antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
IgG
Specificity
M6PR polyclonal antibody detects endogenous levels of M6PR protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Form/Format
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Sequence Length
277
Applicable Applications for anti-M6PR antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
WB: 1:500-1:2000
IHC: 1:50-1:200
Immunogen
Recombinant full length Human M6PR.
Preparation and Storage
Store at 4 degree C short term.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot analysis of extracts of Mouse kidney cell line, using M6PR antibody.)

Western Blot (WB) (Western Blot analysis of extracts of Mouse kidney cell line, using M6PR antibody.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human liver injury using M6PR antibody at dilution of 1:100 (x40 lens).)

Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded human liver injury using M6PR antibody at dilution of 1:100 (x40 lens).)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human gastric using M6PR antibody at dilution of 1:100 (x40 lens).)

Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded human gastric using M6PR antibody at dilution of 1:100 (x40 lens).)
Related Product Information for anti-M6PR antibody
CD-MPR (cation-dependent mannose-6-phosphate receptor) is an oligomeric transmembrane protein that plays a critical role in the intracellular delivery of phosphorylated lysosomal enzymes from the trans-Golgi network (TGN). Intracellular trafficking of CD-MPR is mediated by sorting signals in its 67 amino acid cytoplasmic tail, which prevent it from entering the lysosome, where it would be degraded. CD-MPR is predominantly expressed in mouse testicular germ cells and shows differentiated expression during maturation of rat spermatozoa. Increased expression of CD-MPR in Alzheimer's disease and the location of the CD-MPR gene next to a region on chromosome 12 which is possibly linked to the disease indicate that CD-MPR may play a role in Alzheimer's disease.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
~ 31kDa
NCBI Official Full Name
cation-dependent mannose-6-phosphate receptor isoform 1
NCBI Official Synonym Full Names
mannose-6-phosphate receptor, cation dependent
NCBI Official Symbol
M6PR
NCBI Official Synonym Symbols
SMPR; MPR46; CD-MPR; MPR 46; MPR-46; CD-M6PR
NCBI Protein Information
cation-dependent mannose-6-phosphate receptor
UniProt Protein Name
Cation-dependent mannose-6-phosphate receptor
UniProt Gene Name
M6PR
UniProt Synonym Gene Names
MPR46; MPRD; CD Man-6-P receptor; CD-MPR; MPR 46

NCBI Description

This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011]

Uniprot Description

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.

Research Articles on M6PR

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Product Notes

The M6PR m6pr (Catalog #AAA3011488) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The M6PR Polyclonal Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's M6PR can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). WB: 1:500-1:2000 IHC: 1:50-1:200. Researchers should empirically determine the suitability of the M6PR m6pr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "M6PR, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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