Rabbit anti-Human, Mouse LZP Polyclonal Antibody | anti-LZP antibody

LZP (OIT3, LZP, Oncoprotein-induced transcript 3 protein, Liver-specific zona pellucida domain-containing protein) (MaxLight 550)

Cat. Num. AAA6317831

• Gene Names: OIT3; LZP
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
• Synonyms: LZP; Polyclonal Antibody; LZP (OIT3; Oncoprotein-induced transcript 3 protein; Liver-specific zona pellucida domain-containing protein) (MaxLight 550); OIT3; Liver-specific zona pellucida domain-containing protein; anti-LZP antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.

• Applicable Applications for anti-LZP antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:50-100; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: OIT3 antibody is generated from rabbits immunized with a Gst fusion protein from human OIT3.
• Conjugate: MaxLight550
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western blot analysis of LZP (arrow) using rabbit polyclonal LZP Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the LZP gene.)

Western Blot (WB)

(LZP Antibody western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the LZP antibody detected the LZP protein (arrow).)

Related Product Information for anti-LZP antibody

May be involved in hepatocellular function and development.

Product Categories/Family for anti-LZP antibody

Antibodies; Oncoproteins

References

Shen, H.L., et al. Mol. Cell. Biochem. 321 (1-2), 73-83 (2009): Yang, H., et al. FEBS Lett. 578(3):236-238(2004). Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003). Xu, Z.G., et al. Hepatology 38(3):735-744(2003).

NCBI and Uniprot Product Information

• NCBI GI #: 22749297
• NCBI GeneID: 170392
• NCBI Accession #: NP_689848.1
• NCBI GenBank Nucleotide #: NM_152635.2
• UniProt Accession #: Q8WWZ8; Q8N1M8; A0AVP3
• Molecular Weight: 34,911 Da
• NCBI Official Full Name: oncoprotein-induced transcript 3 protein
• NCBI Official Synonym Full Names: oncoprotein induced transcript 3
• NCBI Official Symbol: OIT3
• NCBI Official Synonym Symbols: LZP
• NCBI Protein Information: oncoprotein-induced transcript 3 protein
• UniProt Protein Name: Oncoprotein-induced transcript 3 protein
• UniProt Gene Name: OIT3
• UniProt Synonym Gene Names: LZP
• UniProt Entry Name: OIT3_HUMAN

NCBI Description

This gene was identified due to its downregulation in hepatocarcinomas. The encoded protein may be involved in liver development and function. [provided by RefSeq, Sep 2016]

Uniprot Description

LZP: a liver-specific protein possibly involved in hepatocellular function and development. Contains 3 epidermal growth factor (EGF)-like domains and a ZP domain. Human LZP is expressed specifically in liver out of 23 tissues examined, and its mouse counterpart was detected at very early stage during embryo development.

Protein type: Secreted; Calcium-binding; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10q22.1

Cellular Component: nuclear envelope

Molecular Function: calcium ion binding