Rabbit anti-Human Lymphotoxin beta Receptor Polyclonal Antibody | anti-LTBR antibody

Lymphotoxin beta Receptor (LTBR, CD18, TNFCR, TNFR3, D12S370, TNFR-RP, TNFRSF3, Tumor Necrosis Factor C Receptor, Tumor Necrosis Factor Receptor Superfamily Member 3, TNFR2-RP, LT-BETA-R, TNF-R-III) (HRP)

Cat. Num. AAA6425048

• Gene Names: LTBR; CD18; TNFCR; TNFR3; D12S370; TNFR-RP; TNFRSF3; TNFR2-RP; LT-BETA-R; TNF-R-III
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by affinity chromatography.
• Synonyms: Lymphotoxin beta Receptor; Polyclonal Antibody; Lymphotoxin beta Receptor (LTBR; CD18; TNFCR; TNFR3; D12S370; TNFR-RP; TNFRSF3; Tumor Necrosis Factor C Receptor; Tumor Necrosis Factor Receptor Superfamily Member 3; TNFR2-RP; LT-BETA-R; TNF-R-III) (HRP); anti-LTBR antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human LTBR.
• Purity/Purification: Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
• Concentration: ~1mg/ml (varies by lot)

• Applicable Applications for anti-LTBR antibody: Immunohistochemistry (IHC), Western Blot (WB)
• Application Notes: IHC: 1:50-1:200; WB: 1:500-1:2000; Applications are based on unconjugated antibody.
• Immunogen: Recombinant protein corresponding to human LTBR.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of extracts of mouse liver, using LTBR antibody.)

Product Categories/Family for anti-LTBR antibody

Antibodies; Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 402534565
• NCBI GeneID: 4055
• NCBI Accession #: NP_001257916.1
• NCBI GenBank Nucleotide #: NM_001270987.1
• UniProt Accession #: P36941; B7Z1D2; D3DUR2; F5GXE7
• Molecular Weight: 44,810 Da
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member 3 isoform 2
• NCBI Official Synonym Full Names: lymphotoxin beta receptor
• NCBI Official Symbol: LTBR
• NCBI Official Synonym Symbols: CD18; TNFCR; TNFR3; D12S370; TNFR-RP; TNFRSF3; TNFR2-RP; LT-BETA-R; TNF-R-III
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 3
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 3
• Protein Family: Tumor necrosis factor receptor superfamily
• UniProt Gene Name: LTBR
• UniProt Synonym Gene Names: D12S370; TNFCR; TNFR3; TNFRSF3; TNF-RIII; TNFR-III
• UniProt Entry Name: TNR3_HUMAN

Uniprot Description

LTBR: Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: identical protein binding; protein binding; tumor necrosis factor receptor activity; ubiquitin protein ligase binding

Biological Process: immune response; inflammatory response; multicellular organismal development; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK cascade; regulation of cell proliferation; response to lipopolysaccharide; signal transduction; tumor necrosis factor-mediated signaling pathway