Rabbit anti-Mouse LRSAM1 Polyclonal Antibody | anti-LRSAM1 antibody

LRSAM1, NT (LRSAM1, TAL, E3 ubiquitin-protein ligase LRSAM1, Leucine-rich repeat and sterile alpha motif-containing protein 1, Tsg101-associated ligase) (AP)

Cat. Num. AAA6317417

• Gene Names: LRSAM1; TAL; CMT2P; RIFLE
• Reactivity: Mouse
• Applications: Immunohistochemistry, ELISA, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: LRSAM1; Polyclonal Antibody; NT (LRSAM1; TAL; E3 ubiquitin-protein ligase LRSAM1; Leucine-rich repeat and sterile alpha motif-containing protein 1; Tsg101-associated ligase) (AP); Tsg101-associated ligase; anti-LRSAM1 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
• Sequence Length: 723

• Applicable Applications for anti-LRSAM1 antibody: Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
• Application Notes: IHC: 1:10-50; ELISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: LRSAM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human LRSAM1.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(LRSAM1 Antibody (N-term) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the LRSAM1 antibody detected the LRSAM1 protein (arrow).)

Immunohistochemistry (IHC)

(LRSAM1 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of LRSAM1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Related Product Information for anti-LRSAM1 antibody

LRSAM1 is a multifunctional RING finger protein that selectively regulates cell adhesion molecules, has ubiquitin ligase activity, and plays a role in receptor endocytosis and viral budding (Li et al., 2003 [PubMed 14635195]; Amit et al., 2004 [PubMed 15256501]).

Product Categories/Family for anti-LRSAM1 antibody

Antibodies; Ubiquitin Ligases

References

Markson, G., et al. Genome Res. 19(10):1905-1911(2009). van Wijk, S.J., et al. Mol. Syst. Biol. 5, 295 (2009): McDonald, B., et al. Mol. Biol. Cell 19(2):754-763(2008). Amit, I., et al. Genes Dev. 18(14):1737-1752(2004). Li, B., et al. J. Cell. Biochem. 90(6):1224-1241(2003).

NCBI and Uniprot Product Information

• NCBI GI #: 53729359
• NCBI GeneID: 90678
• NCBI Accession #: NP_612370.3; NP_001177652.1
• NCBI GenBank Nucleotide #: NP_612370.3
• UniProt Accession #: Q6UWE0
• NCBI Official Full Name: E3 ubiquitin-protein ligase LRSAM1 isoform 1
• NCBI Official Synonym Full Names: leucine rich repeat and sterile alpha motif containing 1
• NCBI Official Symbol: LRSAM1
• NCBI Official Synonym Symbols: TAL; CMT2P; RIFLE
• NCBI Protein Information: E3 ubiquitin-protein ligase LRSAM1
• UniProt Protein Name: E3 ubiquitin-protein ligase LRSAM1
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: LRSAM1
• UniProt Synonym Gene Names: TAL; UNQ6496/PRO21356; hTAL
• UniProt Entry Name: LRSM1_HUMAN

NCBI Description

This gene encodes a ring finger protein involved in a variety of functions, including regulation of signaling pathways and cell adhesion, mediation of self-ubiquitylation, and involvement in cargo sorting during receptor endocytosis. Mutations in this gene have been associated with Charcot-Marie-Tooth disease. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jan 2012]