Rabbit LRCH1 Polyclonal Antibody | anti-LRCH1 antibody

LRCH1 Antibody (Center)

Cat. Num. AAA9214864

• Gene Names: LRCH1; NP81; CHDC1
• Reactivity: Human (Predicted Reactivity: Mouse)
• Applications: Western Blot, ELISA
• Purity: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Synonyms: LRCH1; Polyclonal Antibody; LRCH1 Antibody (Center); Leucine-rich repeat and calponin homology domain-containing protein 1; Calponin homology domain-containing protein 1; Neuronal protein 81; NP81; CHDC1; KIAA1016; anti-LRCH1 antibody

• Host: Rabbit
• Reactivity: Human (Predicted Reactivity: Mouse)
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Specificity: This LRCH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 304-333 amino acids from the Central region of human LRCH1.
• Purity/Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
• Sequence Positions: 304-333

• Applicable Applications for anti-LRCH1 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB~~1:1000
• Clone Names: RB42699
• Function: Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. Probably by preventing CDC42 activation, negatively regulates CD4(+) T-cell migration.
• Cellular Location: Cytoplasm.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(LRCH1 Antibody (Center) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the LRCH1 antibody detected the LRCH1 protein (arrow).)

Related Product Information for anti-LRCH1 antibody

This gene encodes a protein with a leucine-rich repeat and
a calponin homology domain. Polymorphism in this gene may be
associated with susceptibililty to knee osteoarthritis. Alternative
splicing results in multiple transcript variants encoding different
isoforms.

Product Categories/Family for anti-LRCH1 antibody

Cell Biology

References

Zintzaras, E., et al. Am. J. Epidemiol. 171(8):851-858(2010)
Jiang, Q., et al. J. Hum. Genet. 53(1):42-47(2008)
Ikegawa, S. Curr Opin Rheumatol 19(5):429-434(2007)
Snelling, S., et al. Rheumatology (Oxford) 46(2):250-252(2007)
Spector, T.D., et al. Arthritis Rheum. 54(2):524-532(2006)

NCBI and Uniprot Product Information

• NCBI GI #: 256017174
• NCBI GeneID: 23143
• NCBI Accession #: NP_001157683.1; NP_001157685.1; NP_055931.1
• NCBI GenBank Nucleotide #: NM_001164211.1
• UniProt Accession #: Q9Y2L9; Q17R43; Q2KHR1; Q5TBU9; Q7Z5F6; Q7Z5F7; B7ZLL5; F8W6F0
• Molecular Weight: 80875
• NCBI Official Full Name: leucine-rich repeat and calponin homology domain-containing protein 1 isoform 1
• NCBI Official Synonym Full Names: leucine-rich repeats and calponin homology (CH) domain containing 1
• NCBI Official Symbol: LRCH1
• NCBI Official Synonym Symbols: NP81; CHDC1
• NCBI Protein Information: leucine-rich repeat and calponin homology domain-containing protein 1
• UniProt Protein Name: Leucine-rich repeat and calponin homology domain-containing protein 1
• Protein Family: Leucine-rich repeat and calponin homology domain-containing protein
• UniProt Gene Name: LRCH1
• UniProt Synonym Gene Names: CHDC1; KIAA1016; NP81
• UniProt Entry Name: LRCH1_HUMAN

NCBI Description

This gene encodes a protein with a leucine-rich repeat and a calponin homology domain. Polymorphism in this gene may be associated with susceptibililty to knee osteoarthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2010]

Uniprot Description

LRCH1: 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 13q14.11