Western Blot (WB)
(WB Suggested Anti-LONP2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Human brain)
Rabbit LONP2 Polyclonal Antibody | anti-LONP2 antibody
LONP2 antibody - C-terminal region
Western Blot (WB)
(WB Suggested Anti-LONP2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Human brain)
Western Blot (WB)
(WB Suggested Anti-LONP2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Human brain)
Target Description: LONP2 is an ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. It is necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import
NCBI and Uniprot Product Information
NCBI Description
In human, peroxisomes function primarily to catalyze fatty acid beta-oxidation and, as a by-product, produce hydrogen peroxide and superoxide. The protein encoded by this gene is an ATP-dependent protease that likely plays a role in maintaining overall peroxisome homeostasis as well as proteolytically degrading peroxisomal proteins damaged by oxidation. The protein has an N-terminal Lon N substrate recognition domain, an ATPase domain, a proteolytic domain, and, in some isoforms, a C-terminal peroxisome targeting sequence. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017]
Uniprot Description
LONP2: ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. Belongs to the peptidase S16 family.
Protein type: Protease; EC 3.4.21.-
Chromosomal Location of Human Ortholog: 16q12.1
Cellular Component: peroxisomal matrix; membrane; peroxisome; nucleus
Molecular Function: peptidase activity; protein binding; enzyme binding; protease binding; ATP-dependent peptidase activity; serine-type endopeptidase activity; ATP binding; receptor binding
Biological Process: protein targeting to peroxisome; peroxisome organization and biogenesis; misfolded or incompletely synthesized protein catabolic process; protein import into peroxisome matrix; regulation of fatty acid beta-oxidation; protein processing; response to organic cyclic substance
Research Articles on LONP2
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Product Notes
The LONP2 lonp2 (Catalog #AAA3214876) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The LONP2 antibody - C-terminal region reacts with Dog, Horse, Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's LONP2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the LONP2 lonp2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: AICRAVAVKV AEGQHKEAKL DRSDVTEREG CREHILEDEK PESISDTTDL. It is sometimes possible for the material contained within the vial of "LONP2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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