Rabbit anti-Human LMX1A Polyclonal Antibody | anti-LMX1A antibody

LMX1A Antibody

Cat. Num. AAA7050919

• Gene Names: LMX1A; LMX1; LMX1.1
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >95%, Protein G purified
• Synonyms: LMX1A; Polyclonal Antibody; LMX1A Antibody; LIM homeobox transcription factor 1-alpha (LIM/homeobox protein 1.1) (LMX-1.1) (LIM/homeobox protein LMX1A); anti-LMX1A antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid

• Applicable Applications for anti-LMX1A antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB:1:1000-1:5000; IHC:1:20-1:200
• Immunogen: Recombinant Human LIM homeobox transcription factor 1-alpha protein (9-86AA)
• Conjugate: Non-conjugated
• Storage Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
• Species: Homo sapiens (Human)
• Research Area: Neuroscience
• Target Names: LMX1A
• Preparation and Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Western Blot (WB)

(Western BlotPositive WB detected in: Rat brain tissue,Rat liver tissueAll lanes: LMX1A antibody at 3ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 43,15 KDaObserved band size: 43 KDa)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human pancreatic tissue using MBS7050919 at dilution of 1:100)

Related Product Information for anti-LMX1A antibody

Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 291327513
• NCBI GeneID: 4009
• NCBI Accession #: NP_001167540.1
• NCBI GenBank Nucleotide #: NM_001174069.1
• UniProt Accession #: Q8TE12; Q0VDB5; Q5VWG4; Q8TE11; B3KXP6
• NCBI Official Full Name: LIM homeobox transcription factor 1-alpha
• NCBI Official Synonym Full Names: LIM homeobox transcription factor 1 alpha
• NCBI Official Symbol: LMX1A
• NCBI Official Synonym Symbols: LMX1; LMX1.1
• NCBI Protein Information: LIM homeobox transcription factor 1-alpha
• UniProt Protein Name: LIM homeobox transcription factor 1-alpha
• Protein Family: LIM homeobox transcription factor
• UniProt Gene Name: LMX1A
• UniProt Synonym Gene Names: LMX-1.1
• UniProt Entry Name: LMX1A_HUMAN

NCBI Description

This gene encodes a homeodomain and LIM-domain containing protein. The encoded protein is a transcription factor that acts as a positive regulator of insulin gene transcription. This gene also plays a role in the development of dopamine producing neurons during embryogenesis. Mutations in this gene are associated with an increased risk of developing Parkinson's disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

Uniprot Description

LMX1A: Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; DNA-binding; Motility/polarity/chemotaxis; Transcription factor

Chromosomal Location of Human Ortholog: 1q24.1

Molecular Function: protein binding

Biological Process: positive regulation of transcription from RNA polymerase II promoter