Western Blot (WB)
(Western blot analysis of LMTK2 (arrow) using rabbit polyclonal LMTK2 Antibody (Center). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the LMTK2 gene (Lane 2) (Origene Technologies).)
Rabbit anti-Human LMTK2 Polyclonal Antibody | anti-LMTK2 antibody
LMTK2 Antibody (Center)
Western Blot (WB)
(Western blot analysis of LMTK2 (arrow) using rabbit polyclonal LMTK2 Antibody (Center). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the LMTK2 gene (Lane 2) (Origene Technologies).)
Western Blot (WB)
(Western blot analysis of LMTK2 (arrow) using rabbit polyclonal LMTK2 Antibody (Center). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the LMTK2 gene (Lane 2) (Origene Technologies).)
Hillier, L.W., et al., Nature 424(6945):157-164 (2003).
Scherer, S.W., et al., Science 300(5620):767-772 (2003).
Kesavapany, S., et al., J. Neurosci. 23(12):4975-4983 (2003).
Wang, H., et al., J. Biol. Chem. 277(51):49605-49612 (2002).
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009]
Uniprot Description
Lmr2: a tyrosine kinase of the Lmr family that apparently phosphorylates Serine and Threonine residues. Associates with PP1C and Inh2 to form a regulatory complex that localizes to membranes. Enriched in brain and muscle. Inhibited in living cells by addition of nerve growth factor or serum. Appears to be inhibited by Cdk5/p35.
Protein type: Protein kinase, TK; EC 2.7.11.1; Membrane protein, integral; Kinase, protein; Protein kinase, tyrosine (receptor); Membrane protein, multi-pass; TK group; Lmr family
Chromosomal Location of Human Ortholog: 7q21.3
Cellular Component: Golgi apparatus; recycling endosome; perinuclear region of cytoplasm; early endosome; integral to membrane
Molecular Function: protein serine/threonine kinase activity; protein binding; protein phosphatase inhibitor activity; ATP binding
Biological Process: receptor recycling; peptidyl-serine phosphorylation; early endosome to late endosome transport; protein amino acid autophosphorylation; negative regulation of catalytic activity; peptidyl-threonine phosphorylation; transferrin transport; endocytic recycling; protein amino acid phosphorylation
Research Articles on LMTK2
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Product Notes
The LMTK2 lmtk2 (Catalog #AAA9214200) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 668-697. The LMTK2 Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's LMTK2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the LMTK2 lmtk2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LMTK2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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