Rabbit lktA Polyclonal Antibody | anti-lktA antibody
Rabbit anti-Mannheimia haemolytica (Pasteurella haemolytica) lktA Polyclonal Antibody
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH7.4
2. 1mL preimmune serum (negative control)
3. 10mg rabbit polyclonal antibody purified by Protein A/G.
2. Antibody titer > 1: 64,000 confirmed by ELISA
3. Western Blot positive for the immunogen protein (Not applicable for synthetic peptide).
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NCBI and Uniprot Product Information
Uniprot Description
Function: Pasteurella leukotoxins are exotoxins that attack host leukocytes and especially polymorphonuclear cells, by causing cell rupture. The leukotoxin binds to the host LFA-1 integrin and induces a signaling cascade leading to many biological effects, including tyrosine phosphorylation of the CD18 tail, elevation of the intracellular Ca2+ and lysis of the host cell
By similarity. This leukotoxin is a major contributor to the pathogenesis of lung injury in ovine pneumonic pasteurellosis. It has also weak hemolytic activity.
Subcellular location: Secreted
By similarity. Host cell membrane; Multi-pass membrane protein
By similarity.
Domain: The transmembrane domains are believed to be involved in pore formation in target cells
By similarity.The Gly-rich region is probably involved in calcium binding, which is required for target cell-binding and cytolytic activity
By similarity.The C-terminal domain contains an export signal that is recognized by the ABC transporter complex LktBD
By similarity.
Post-translational modification: Acylated by LktC. The toxin only becomes active when modified
By similarity.
Miscellaneous: The lktCABD operon has a complex mosaic structure that has been derived by extensive inter- and intraspecies horizontal DNA transfer and intragenic recombination events.
Sequence similarities: Belongs to the RTX prokaryotic toxin (TC 1.C.11) family. [View classification]Contains 5 hemolysin-type calcium-binding repeats.
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Product Notes
The lktA lkta (Catalog #AAA7160437) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-Mannheimia haemolytica (Pasteurella haemolytica) lktA Polyclonal Antibody reacts with Mannheimia haemolytica (Pasteurella haemolytica) and may cross-react with other species as described in the data sheet. AAA Biotech's lktA can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), WB (Western Blot) (ensure identification of antigen). Researchers should empirically determine the suitability of the lktA lkta for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "lktA, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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