Rabbit anti-Human LINGO Polyclonal Antibody | anti-LINGO1 antibody

LINGO, phosphorylated (1, phosphorylated (pS596) (LRRN6A, Lingo1, Lern1, Lrrn6a, Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1, Leucine-rich repeat neuronal protein 1, Leucine-rich repeat neuronal protei

Cat. Num. AAA642973

• Gene Names: LINGO1; LERN1; LRRN6A; UNQ201
• Reactivity: Human
• Applications: ELISA, Gel Super Shift Assay
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: LINGO; Polyclonal Antibody; phosphorylated (1; phosphorylated (pS596) (LRRN6A; Lingo1; Lern1; Lrrn6a; Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; Leucine-rich repeat neuronal protein 1; Leucine-rich repeat neuronal protei; Anti -LINGO; anti-LINGO1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-LINGO1 antibody: ELISA (EL/EIA), Gel Shift Assay (GS/EMSA)
• Application Notes: Suitable for use in Dot Blot, ELISA; Dilution: ELISA: 1:1,000; Dot blot 1:500
• Immunogen: Phospho-LINGO-1(LRRN6A)-pS596 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide between 582~611 amino acids surrounding pS596 of human LINGO-1(LRRN6A).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Dot Blot (DB)

(Dot blot analysis of anti-Phospho-LINGO-1(LRRN6A)-pS596 Pab on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.)

Related Product Information for anti-LINGO1 antibody

LINGO-1 (LRR and Ig domain-containing Nogo Receptor interating protein) is a nervous system-specific LRR-Ig-containing protein with an important role in CNS biology. LINGO-1 was discovered in a sequence database search for human SLIT homologs that were selectively expressed in the brain. LINGO-1 is a transmembrane protein that is a component of the Nogo-66 receptor complex. It binds NgR1 and p75 and is an additional functional componenet of the NgR1/p75 signaling complex.

Product Categories/Family for anti-LINGO1 antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 50263044
• NCBI GeneID: 84894
• NCBI Accession #: NP_116197.4
• NCBI GenBank Nucleotide #: NM_032808.5
• UniProt Accession #: Q96FE5; Q6NUK3; Q6UXM3; Q6VVG0; Q6VVG1; Q6VVG2; Q8N3K5; Q96K52; D3DW80
• Molecular Weight: 69,876 Da
• NCBI Official Full Name: leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
• NCBI Official Synonym Full Names: leucine rich repeat and Ig domain containing 1
• NCBI Official Symbol: LINGO1
• NCBI Official Synonym Symbols: LERN1; LRRN6A; UNQ201
• NCBI Protein Information: leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; leucine rich repeat neuronal 6A; leucine-rich repeat neuronal protein 1; leucine-rich repeat neuronal protein 6A; leucine-rich repeat and immunoglobilin domain-containing protein 1; leucine-rich repeat and immunoglobulin domain-containing protein 1
• UniProt Protein Name: Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
• Protein Family: Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein
• UniProt Gene Name: LINGO1
• UniProt Synonym Gene Names: LERN1; LRRN6A
• UniProt Entry Name: LIGO1_HUMAN

Uniprot Description

LINGO1: Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q24.3

Cellular Component: plasma membrane; integral to membrane

Molecular Function: epidermal growth factor receptor binding

Biological Process: negative regulation of oligodendrocyte differentiation; nerve growth factor receptor signaling pathway; protein kinase B signaling cascade; negative regulation of axonogenesis; regulation of axonogenesis; neurite development; central nervous system neuron development