Western Blot (WB)
(LILRB1 Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the LILRB1 antibody detected the LILRB1 protein (arrow).)
Rabbit anti-Human LILRB1 Polyclonal Antibody | anti-LILRB1 antibody
LILRB1 Antibody (Center)
Western Blot (WB)
(LILRB1 Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the LILRB1 antibody detected the LILRB1 protein (arrow).)
Western Blot (WB)
(LILRB1 Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the LILRB1 antibody detected the LILRB1 protein (arrow).)
Anti-LILRB1
(LILRB1 All lanes : Anti-LILRB1 Antibody (Center) at 1:500-1:2000 dilution Lane 1: Daudi whole cell lysate Lane 2: Raji whole cell lysate Lane 3:Ramos whole cell lysate Lane 4: SH-SY5Y whole cell lysate Lysates/proteins at 20 ?g per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution.Predictedband size : 71 kDa Blocking/Dilutionbuffer: 5% NFDM/TBST.)
Anti-LILRB1
(LILRB1 All lanes : Anti-LILRB1 Antibody (Center) at
1:500-1:2000 dilution Lane 1: Daudi whole cell lysate Lane 2: Raji whole cell lysate Lane 3:Ramos whole cell lysate Lane 4: SH-SY5Y whole
cell lysate Lysates/proteins at 20 ?g per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution.Predictedband size : 71 kDa Blocking/Dilutionbuffer: 5% NFDM/TBST.)
receptor (LIR) family, which is found in a gene cluster at
chromosomal region 19q13.4. The encoded protein belongs to the
subfamily B class of LIR receptors which contain two or four
extracellular immunoglobulin domains, a transmembrane domain, and
two to four cytoplasmic immunoreceptor tyrosine-based inhibitory
motifs (ITIMs). The receptor is expressed on immune cells where it
binds to MHC class I molecules on antigen-presenting cells and
transduces a negative signal that inhibits stimulation of an immune
response. It is thought to control inflammatory responses and
cytotoxicity to help focus the immune response and limit
autoreactivity. Multiple transcript variants encoding different
isoforms have been found for this gene.
Davidson, C.L., et al. Hum. Immunol. 71(10):942-949(2010)
Huang, J., et al. J. Virol. 84(18):9463-9471(2010)
Godal, R., et al. Biol. Blood Marrow Transplant. 16(5):612-621(2010)
Lamar, D.L., et al. Blood 115(16):3278-3286(2010)
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
LILRB1: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 19q13.4
Cellular Component: cytoplasm; plasma membrane; integral to membrane; extracellular region; external side of plasma membrane
Molecular Function: MHC class I receptor activity; protein homodimerization activity; MHC class I protein binding; HLA-A specific inhibitory MHC class I receptor activity; SH2 domain binding; HLA-B specific inhibitory MHC class I receptor activity; protein phosphatase 1 binding
Biological Process: immune response-inhibiting cell surface receptor signaling pathway; negative regulation of calcium ion transport; regulation of immune response; negative regulation of mononuclear cell proliferation; positive regulation of apoptosis; response to virus; negative regulation of natural killer cell mediated cytotoxicity; negative regulation of endocytosis; signal transduction; negative regulation of cell cycle; negative regulation of cytokine secretion during immune response; negative regulation of interferon-gamma biosynthetic process; negative regulation of serotonin secretion; negative regulation of alpha-beta T cell activation; negative regulation of T cell proliferation; T cell proliferation during immune response; negative regulation of interferon-gamma production; receptor internalization; negative regulation of T cell mediated cytotoxicity; interferon-gamma production; Fc receptor mediated inhibitory signaling pathway; positive regulation of transcription from RNA polymerase II promoter; negative regulation of tumor necrosis factor biosynthetic process; positive regulation of cytolysis; positive regulation of defense response to virus by host; defense response to virus
Research Articles on LILRB1
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Product Notes
The LILRB1 lilrb1 (Catalog #AAA9210505) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The LILRB1 Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's LILRB1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:500-1:2000. Researchers should empirically determine the suitability of the LILRB1 lilrb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LILRB1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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