Rabbit anti-Human LILRA2 Polyclonal Antibody | anti-LILRA2 antibody

LILRA2 Antibody

Cat. Num. AAA9509658

• Gene Names: LILRA2; ILT1; LIR7; CD85H; LIR-7
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified from rabbit antiserum by affinity-chromatography using immunogen.
• Synonyms: LILRA2; Polyclonal Antibody; LILRA2 Antibody; Leukocyte immunoglobulin-like receptor subfamily A member 2; Leukocyte immunoglobulin-like receptor 7; LIR-7; Immunoglobulin-like transcript 1; ILT-1; CD85h antigen; anti-LILRA2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: LILRA2 Antibody detects endogenous levels of LILRA2.
• Purity/Purification: Purified from rabbit antiserum by affinity-chromatography using immunogen.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 437

• Applicable Applications for anti-LILRA2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500~1:1000; ELISA: 1:10000
• Target Modification: Unmodified/Total
• Immunogen: The antiserum was produced against synthesized peptide derived from human LILRA2.
• Immunogen Range: 33-82
• Preparation and Storage: Stable at -20 degree C for at least 1 year.

Western Blot (WB)

(Western blot analysis of the lysates from HepG2 cells using LILRA2 antibody.)

NCBI and Uniprot Product Information

• NCBI GI #: 590122030
• NCBI GeneID: 11027
• NCBI Accession #: NP_006857.2
• NCBI GenBank Nucleotide #: NM_006866.3
• UniProt Accession #: Q8N149; O75020
• Molecular Weight: 52 kDa
• NCBI Official Full Name: leukocyte immunoglobulin-like receptor subfamily A member 2 isoform b
• NCBI Official Synonym Full Names: leukocyte immunoglobulin like receptor A2
• NCBI Official Symbol: LILRA2
• NCBI Official Synonym Symbols: ILT1; LIR7; CD85H; LIR-7
• NCBI Protein Information: leukocyte immunoglobulin-like receptor subfamily A member 2
• UniProt Protein Name: Leukocyte immunoglobulin-like receptor subfamily A member 2
• Protein Family: Leukocyte immunoglobulin-like receptor subfamily
• UniProt Gene Name: LILRA2
• UniProt Synonym Gene Names: ILT1; LIR7; LIR-7

NCBI Description

This gene encodes a member of a family of immunoreceptors that are expressed predominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer cells. The encoded protein is an activating receptor that inhibits dendritic cell differentiation and antigen presentation and suppresses innate immune response. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and there is a pseudogene for this gene on chromosome 3. [provided by RefSeq, Mar 2014]

Uniprot Description

Part of the innate immune responses against microbial infection (PubMed:12529506, PubMed:27572839). Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans (PubMed:27572839). Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling (PubMed:27572839). Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind cleaved IgA1 (PubMed:27572839). Binding of N-terminally truncated immunoglobulins mediates activation of neutrophils (PubMed:27572839). In monocytes, activation leads to the release of CSF2, CF3, IL6, CXCL8 and CCL3 and down-regulates responses to bacterial lipopolysaccharide (LPS), possibly via down-regulation of TLR4 expression and reduced signaling via TLR4 (PubMed:22479404). In eosinophils, activation by ligand binding leads to the release of RNASE2, IL4 and leukotriene C4 (PubMed:12529506). Does not bind class I MHC antigens (PubMed:19230061).