Rabbit anti-Human LILRA2 Polyclonal Antibody | anti-LILRA2 antibody

LILRA2, ID (LILRA2, ILT1, LIR7, Leukocyte immunoglobulin-like receptor subfamily A member 2, CD85 antigen-like family member H, Immunoglobulin-like transcript 1, Leukocyte immunoglobulin-like receptor 7, CD85h) (AP)

Cat. Num. AAA6316042

• Gene Names: LILRA2; ILT1; LIR7; CD85H; LIR-7
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: LILRA2; Polyclonal Antibody; ID (LILRA2; ILT1; LIR7; Leukocyte immunoglobulin-like receptor subfamily A member 2; CD85 antigen-like family member H; Immunoglobulin-like transcript 1; Leukocyte immunoglobulin-like receptor 7; CD85h) (AP); CD85h; anti-LILRA2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-LILRA2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: LILRA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-89 amino acids from the Central region of human LILRA2.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(LILRA2 Antibody (Center) western blot analysis in NCI-H292,NCI-H460 and A549 cell line lysates (35ug/lane).This demonstrates the LILRA2 antibody detected the LILRA2 protein (arrow).)

Flow Cytometry (FC/FACS)

(LILRA2 Antibody (Center) flow cytometric analysis of A549 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)

Related Product Information for anti-LILRA2 antibody

Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function (see, e.g., LILRB1, MIM 604811). LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades. One member of subfamily A (LILRA3; MIM 604818) lacks a transmembrane region and is presumed to be a soluble receptor.

Product Categories/Family for anti-LILRA2 antibody

Antibodies; CD Markers

References

Mosbruger, T.L., et al. J. Infect. Dis. 201(9):1371-1380(2010). Davila, S., et al. Genes Immun. 11(3):232-238(2010). Jones, D.C., et al. Eur. J. Immunol. 39(11):3195-3206(2009). Chen, Y., et al. J. Mol. Biol. 386(3):841-853(2009). Mamegano, K., et al. Genes Immun. 9(3):214-223(2008).

NCBI and Uniprot Product Information

• NCBI GI #: 5803068
• NCBI GeneID: 11027
• NCBI Accession #: NP_006857.1
• NCBI GenBank Nucleotide #: NM_006866.2
• UniProt Accession #: Q8N149; O75020
• Molecular Weight: 48,023 Da
• NCBI Official Full Name: leukocyte immunoglobulin-like receptor subfamily A member 2 isoform b
• NCBI Official Synonym Full Names: leukocyte immunoglobulin like receptor A2
• NCBI Official Symbol: LILRA2
• NCBI Official Synonym Symbols: ILT1; LIR7; CD85H; LIR-7
• NCBI Protein Information: leukocyte immunoglobulin-like receptor subfamily A member 2
• UniProt Protein Name: Leukocyte immunoglobulin-like receptor subfamily A member 2
• Protein Family: Leukocyte immunoglobulin-like receptor subfamily
• UniProt Gene Name: LILRA2
• UniProt Synonym Gene Names: ILT1; LIR7; ILT-1; LIR-7
• UniProt Entry Name: LIRA2_HUMAN

NCBI Description

This gene encodes a member of a family of immunoreceptors that are expressed predominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer cells. The encoded protein is an activating receptor that inhibits dendritic cell differentiation and antigen presentation and suppresses innate immune response. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and there is a pseudogene for this gene on chromosome 3. [provided by RefSeq, Mar 2014]

Uniprot Description

LILRA2: Does not bind class I MHC antigens. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: integral to membrane; extracellular region

Molecular Function: receptor activity; antigen binding

Biological Process: immune system process; defense response; signal transduction