Rabbit anti-Human LI Cadherin Polyclonal Antibody | anti-CDH17 antibody

LI Cadherin Rabbit pAb

Cat. Num. AAA4755541

• Gene Names: CDH17; HPT1; CDH16; HPT-1
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry, Immunoprecipitation
• Purity: Affinity purified
• Synonyms: LI Cadherin; Polyclonal Antibody; LI Cadherin Rabbit pAb; cadherin 17; anti-CDH17 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Expressed in the gastrointestinal tract and pancreatic duct. Not detected in kidney, lung, liver, brain, adrenal gland and skin.
• Purity/Purification: Affinity purified
• Form/Format: Supplied in 50nM Tris-Glycine(pH7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

• Applicable Applications for anti-CDH17 antibody: Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P), Immunoprecipitation (IP)
• Application Notes: WB: 1:2000; IHC: 1:50; IP: 1:20
• Immunogen: A synthetic peptide of human LI Cadherin
• Conjugation: Unconjugated
• Molecular Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.
• Modification: Unmodified
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Western Blot (WB)

(Western blot detection of LI Cadherin in HCT116, SW480 using LI Cadherin Rabbit pAb.Predicted band size:92kDa.Observed band size:120kDa.)

Product Categories/Family for anti-CDH17 antibody

Primary antibody

NCBI and Uniprot Product Information

• NCBI GI #: 221316595
• NCBI GeneID: 1015
• NCBI Accession #: NP_001138135.1
• NCBI GenBank Nucleotide #: NM_001144663.1
• UniProt Accession #: Q12864; Q15336; Q2M2E0
• Molecular Weight: 92,219 Da
• NCBI Official Full Name: cadherin-17
• NCBI Official Synonym Full Names: cadherin 17, LI cadherin (liver-intestine)
• NCBI Official Symbol: CDH17
• NCBI Official Synonym Symbols: HPT1; CDH16; HPT-1
• NCBI Protein Information: cadherin-17; LI cadherin; LI-cadherin; cadherin-16; HPT-1 cadherin; liver-intestine cadherin; human peptide transporter 1; intestinal peptide-associated transporter HPT-1; human intestinal peptide-associated transporter HPT-1
• UniProt Protein Name: Cadherin-17
• Protein Family: Cadherin
• UniProt Gene Name: CDH17
• UniProt Synonym Gene Names: LI-cadherin
• UniProt Entry Name: CAD17_HUMAN

NCBI Description

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

Uniprot Description

CDH17: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 8q22.1

Cellular Component: basolateral plasma membrane; integral to membrane; plasma membrane

Molecular Function: transporter activity; calcium ion binding; proton-dependent oligopeptide secondary active transmembrane transporter activity

Biological Process: intercellular junction assembly and maintenance; transport; calcium-dependent cell-cell adhesion; oligopeptide transport; homophilic cell adhesion; cell adhesion