Rabbit anti-Mouse LHX6 Polyclonal Antibody | anti-LHX6 antibody

LHX6, CT (LHX6, LHX6.1, LIM/homeobox protein Lhx6, LIM/homeobox protein Lhx6.1) (Biotin)

Cat. Num. AAA6316000

• Gene Names: LHX6; LHX6.1
• Reactivity: Mouse
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: LHX6; Polyclonal Antibody; CT (LHX6; LHX6.1; LIM/homeobox protein Lhx6; LIM/homeobox protein Lhx6.1) (Biotin); LIM/homeobox protein Lhx6.1; anti-LHX6 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
• Sequence Length: 377

• Applicable Applications for anti-LHX6 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: LHX6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 333-363 amino acids from the C-terminal region of human LHX6.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(LHX6 Antibody (C-term) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the LHX6 antibody detected the LHX6 protein (arrow).)

Related Product Information for anti-LHX6 antibody

This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and may be involved in the control of differentiation and development of neural and lymphoid cells. Two alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined.

Product Categories/Family for anti-LHX6 antibody

Antibodies; Transcription Factors; Zinc; Ring; Homeobox

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Jung, S., et al. Oncol. Rep. 23(6):1675-1682(2010). Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010). Estecio, M.R., et al. Oncogene 25(36):5018-5026(2006). Humphray, S.J., et al. Nature 429(6990):369-374(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 134284361
• NCBI GeneID: 26468
• NCBI Accession #: NP_954629.2; NP_055183.2
• NCBI GenBank Nucleotide #: NP_954629.2
• UniProt Accession #: Q9UPM6
• NCBI Official Full Name: LIM/homeobox protein Lhx6 isoform 2
• NCBI Official Synonym Full Names: LIM homeobox 6
• NCBI Official Symbol: LHX6
• NCBI Official Synonym Symbols: LHX6.1
• NCBI Protein Information: LIM/homeobox protein Lhx6
• UniProt Protein Name: LIM/homeobox protein Lhx6
• Protein Family: LIM/homeobox protein
• UniProt Gene Name: LHX6
• UniProt Synonym Gene Names: LHX6.1; LIM homeobox protein 6
• UniProt Entry Name: LHX6_HUMAN

NCBI Description

This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein has tandem LIM domains as well as a DNA-binding homeodomain. The protein functions as a transcription factor involved in embryogenesis and head development and is highly expressed in neural crest derived mesenchyme cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017]

Uniprot Description

LHX6: Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 9q33.2

Cellular Component: nucleus

Molecular Function: protein binding; sequence-specific DNA binding; transcription factor activity; zinc ion binding

Biological Process: cell maturation; cerebral cortex GABAergic interneuron migration; cerebral cortex radially oriented cell migration; cerebral cortex tangential migration; forebrain neuron fate commitment; regulation of transcription, DNA-dependent; transcription, DNA-dependent