Western Blot (WB)
(LHX4 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the LHX4 antibody detected the LHX4 protein (arrow).)
Rabbit LHX4 Polyclonal Antibody | anti-LHX4 antibody
LHX4 Antibody (Center)
Western Blot (WB)
(LHX4 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the LHX4 antibody detected the LHX4 protein (arrow).)
Western Blot (WB)
(LHX4 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the LHX4 antibody detected the LHX4 protein (arrow).)
contains the LIM domain, a unique cysteine-rich zinc-binding
domain. The encoded protein may function as a transcriptional
regulator and be involved in control of differentiation and
development of the pituitary gland. Mutations in this gene are
associated with syndromic short stature and pituitary and hindbrain
defects. An alternative splice variant has been described but its
biological nature has not been determined.
Castinetti, F., et al. J. Clin. Endocrinol. Metab. 93(7):2790-2799(2008)
Pfaeffle, R.W., et al. J. Clin. Endocrinol. Metab. 93(3):1062-1071(2008)
Liu, S., et al. Biochem. Biophys. Res. Commun. 366(1):36-41(2008)
de Bruijn, D.R., et al. Oncogene 27(5):653-662(2008)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor involved in the control of differentiation and development of the pituitary gland. Mutations in this gene cause combined pituitary hormone deficiency 4. [provided by RefSeq, Dec 2010]
Uniprot Description
LHX4: May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Defects in LHX4 are the cause of pituitary hormone deficiency combined type 4 (CPHD4); also known as short stature pituitary and cerebellar defects and small sella turcica. The disorder is characterized by short stature, pituitary and cerebellar defects, and small transverse depression crossing the midline on the superior surface of the body of the sphenoid bone which houses the pituitary gland. A chromosomal aberration involving LHX4 may be a cause of acute lymphoblastic leukemia. Translocation t(1;14)(q25;q32) with IGHG1.
Protein type: Oncoprotein; DNA-binding
Chromosomal Location of Human Ortholog: 1q25.2
Cellular Component: nucleus
Molecular Function: zinc ion binding; sequence-specific DNA binding
Biological Process: organ morphogenesis; regulation of transcription, DNA-dependent; transcription, DNA-dependent; medial motor column neuron differentiation; motor axon guidance; placenta development; negative regulation of apoptosis
Disease: Pituitary Hormone Deficiency, Combined, 4
Research Articles on LHX4
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Product Notes
The LHX4 lhx4 (Catalog #AAA9205616) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 133-161. The LHX4 Antibody (Center) reacts with Human (Predicted Reactivity: Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's LHX4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the LHX4 lhx4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LHX4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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