Rabbit LHCGR / LHR / LH Receptor Polyclonal Antibody | anti-LHCGR antibody

Rabbit Polyclonal to Human LHCGR / LHR / LH Receptor

Cat. Num. AAA244081

• Gene Names: LHCGR; HHG; LHR; LCGR; LGR2; ULG5; LHRHR; LSH-R; LH/CGR; LH/CG-R
• Reactivity: Reactivity: Human; Predicted Reactivity: Monkey, Rat, Dog
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: LHCGR / LHR / LH Receptor; Polyclonal Antibody; Rabbit Polyclonal to Human LHCGR / LHR / LH Receptor; Anti-LHCGR / LHR / LH Receptor Antibody (C-Terminus) IHC-plus; LHCGR; HCG receptor; HHG; LCGR; LH/CGR; LHR; LH receptor; LHRHR; Lutropin receptor; LGR2; LH/CG-R; LSH-R; ULG5; Luteinizing hormone receptor; Human LHCGR; LH Receptor; anti-LHCGR antibody

• Host: Rabbit
• Reactivity: Reactivity: Human; Predicted Reactivity: Monkey, Rat, Dog
• Clonality: Polyclonal
• Specificity: Human hCG receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 699

• Applicable Applications for anti-LHCGR antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (5 ug/ml)
• Target Species: Human
• Target: LHCGR/LHR/LH Receptor
• Immunogen Description: Synthetic 19 amino acid peptide from C-terminus of human hCG receptor. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey, Marmoset, Rat, Dog, Panda (95%); Bovine, Bat, Rabbit, Horse (89%); Ferret (84%).
• Immunogen Type: Synthetic peptide
• Immunogen: LHCGR / LHR / LH Receptor antibody was raised against synthetic 19 amino acid peptide from C-terminus of human hCG receptor. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey, Marmoset, Rat, Dog, Panda (95%); Bovine, Bat, Rabbit, Horse (89%); Ferret (84%).
• Antigen Modification: C-Terminus
• Preparation and Storage: Upon arrival: Aliquot and store undiluted at -20 degree C or below for up to 1 year. Can be stored undiluted at 4 degree C for up to 1 month. Avoid freeze thaw cycles.

Immunohistochemistry (IHC)

(Anti-LHCGR / LHR / LH Receptor antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-LHCGR / LHR / LH Receptor antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-hCG receptor antibody IHC of human ovary, corpus luteum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-LHCGR antibody

LHCGR is a Glycoprotein Hormone Receptor for both luteinizing hormone and choriogonadotropin. It is expressed in the reproductive organs of both males and females. In males, the luteinizing hormone/choriogonadotropin receptor is involved in the development and function of Leydig cells. Mutations in this gonadotropin receptor can result in disorders of male secondary sexual character development, such as familial male precocious puperty and male pseudohermaphroditism, or lead to adenomas of the testis. In females, inactivating mutations of LHCGR cause hypergonadotrophic hypogonadism with primary amenorrhea or oligomenorrhea, cystic ovaries, and infertility. LHCGR has many alternatively spliced isoforms that affect where this gene is expressed.

Product Categories/Family for anti-LHCGR antibody

Family: GPCR; Subfamily: Glycoprotein hormone

NCBI and Uniprot Product Information

• NCBI GI #: 106067657
• NCBI GeneID: 3973
• NCBI Accession #: NP_000224.2
• NCBI GenBank Nucleotide #: NM_000233.3
• UniProt Accession #: P22888; Q14751; Q15996; Q9UEW9
• NCBI Official Full Name: lutropin-choriogonadotropic hormone receptor
• NCBI Official Synonym Full Names: luteinizing hormone/choriogonadotropin receptor
• NCBI Official Symbol: LHCGR
• NCBI Official Synonym Symbols: HHG; LHR; LCGR; LGR2; ULG5; LHRHR; LSH-R; LH/CGR; LH/CG-R
• NCBI Protein Information: lutropin-choriogonadotropic hormone receptor; hypergonadotropic hypogonadism; lutropin/choriogonadotropin receptor
• UniProt Protein Name: Lutropin-choriogonadotropic hormone receptor
• Protein Family: Lutropin-choriogonadotropic hormone receptor
• UniProt Gene Name: LHCGR
• UniProt Synonym Gene Names: LCGR; LGR2; LHRHR; LH/CG-R; LHR; LSH-R
• UniProt Entry Name: LSHR_HUMAN

NCBI Description

This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. [provided by RefSeq, Jul 2008]

Uniprot Description

LHR: Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Defects in LHCGR are a cause of familial male precocious puberty (FMPP); also known as testotoxicosis. In FMPP the receptor is constitutively activated. Defects in LHCGR are the cause of luteinizing hormone resistance (LHR); also known as Leydig cell hypoplasia in males. LHR is an autosomal recessive disorder characterized by unresponsiveness to luteinizing hormone, defective sexual development in males, and defective follicular development and ovulation, amenorrhea and infertility in females. Two forms of the disorder have been defined in males. Type 1 is a severe form characterized by complete 46,XY male pseudohermaphroditism, low testosterone and high luteinizing hormone levels, total lack of responsiveness to luteinizing and chorionic gonadotropin hormones, lack of breast development, and absent development of secondary male sex characteristics. Type 2, a milder form, displays a broader range of phenotypic expression ranging from micropenis to severe hypospadias. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: integral to plasma membrane; plasma membrane; endosome

Molecular Function: lutropin-choriogonadotropic hormone receptor activity

Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; G-protein coupled receptor protein signaling pathway; male gonad development; adenylate cyclase activation; male genitalia development; positive regulation of inositol trisphosphate biosynthetic process; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); luteinizing hormone signaling pathway; cognition

Disease: Precocious Puberty, Male-limited; Leydig Cell Hypoplasia, Type I