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Western Blot (WB) (Western blot analysis of LGP2 in MDA-MB-361 cell lysate with LGP2 antibody at (A) 0.5 and (B) 1 ug/mL.)

Rabbit LGP2 Polyclonal Antibody | anti-LGP2 antibody

LGP2 Antibody

Gene Names
DHX58; LGP2; RLR-3; D11LGP2; D11lgp2e
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot
Purity
Affinity chromatography purified via peptide column
Synonyms
LGP2; Polyclonal Antibody; LGP2 Antibody; DHX58; likely ortholog of mouse D11lgp2; anti-LGP2 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
678
Applicable Applications for anti-LGP2 antibody
ELISA (EIA), Western Blot (WB)
Immunogen Type
Peptide
Immunogen Description
Raised against a 14 amino acid peptide from near the amino terminus of human LGP2.
Target Name
LGP2
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of LGP2 in MDA-MB-361 cell lysate with LGP2 antibody at (A) 0.5 and (B) 1 ug/mL.)

Western Blot (WB) (Western blot analysis of LGP2 in MDA-MB-361 cell lysate with LGP2 antibody at (A) 0.5 and (B) 1 ug/mL.)
Related Product Information for anti-LGP2 antibody
Anti-viral innate immune responses are triggered by pathogen-associated molecular patters (such as the accumulation of intracellular nucleic acids resulting from virus infections) and represent the first line of defense against numerous infectious organisms. The Toll-like receptors (TLR) 3, 7, 8, and 9 are expressed in immune cells and function as transmembrane pattern recognition receptors to detect foreign nucleic acids. Other proteins that play similar roles, such as RIG-1 and MDA5 are members of a CARD-helicase family and are expressed in the cytoplasm. A third protein, LGP2, is similar to RIG-1 and MDA5, except for lacking a homologous CARD domain. It is thought to act as an element of negative-feedback regulation of intracellular antiviral signaling. At least four isoforms of LGP2 are known to exist.
Product Categories/Family for anti-LGP2 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
Molecular Weight
76,613 Da
NCBI Official Full Name
likely ortholog of mouse D11lgp2, isoform CRA_b
NCBI Official Synonym Full Names
DEXH (Asp-Glu-X-His) box polypeptide 58
NCBI Official Symbol
DHX58
NCBI Official Synonym Symbols
LGP2; RLR-3; D11LGP2; D11lgp2e
NCBI Protein Information
probable ATP-dependent RNA helicase DHX58
UniProt Protein Name
Probable ATP-dependent RNA helicase DHX58
UniProt Gene Name
DHX58
UniProt Synonym Gene Names
D11LGP2E; LGP2; RLR-3; RLR
UniProt Entry Name
DHX58_HUMAN

Uniprot Description

DHX58: Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1- dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate. Belongs to the helicase family. RLR subfamily.

Protein type: Inhibitor; EC 3.6.4.13; Helicase

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: cytoplasm

Molecular Function: protein binding; single-stranded RNA binding; DNA binding; zinc ion binding; double-stranded RNA binding; helicase activity; ATP binding

Biological Process: viral reproduction; negative regulation of innate immune response; metabolic process; response to virus; positive regulation of interferon type I production; innate immune response; negative regulation of interferon type I production; defense response to virus; regulation of innate immune response

Research Articles on LGP2

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Product Notes

The LGP2 dhx58 (Catalog #AAA9406764) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The LGP2 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's LGP2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the LGP2 dhx58 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LGP2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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