Rabbit anti-Human Leukemia Inhibitory Factor (LIF) Polyclonal Antibody | anti-LIF antibody
Biotin-Linked Polyclonal Antibody to Leukemia Inhibitory Factor (LIF)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Uniprot Description
LIF: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes. Belongs to the LIF/OSM family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 22q12.2
Cellular Component: cytosol; extracellular region; extracellular space
Molecular Function: cytokine activity; growth factor activity; leukemia inhibitory factor receptor binding; protein binding; receptor binding
Biological Process: alveolus development; blood vessel remodeling; decidualization; embryo implantation; immune response; leukemia inhibitory factor signaling pathway; multicellular organism development; muscle morphogenesis; negative regulation of cell proliferation; negative regulation of hormone secretion; negative regulation of meiotic nuclear division; neuron development; positive regulation of astrocyte differentiation; positive regulation of cell proliferation; positive regulation of macrophage differentiation; positive regulation of MAPK cascade; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-serine phosphorylation of STAT protein; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of STAT protein; stem cell differentiation; stem cell maintenance; tyrosine phosphorylation of STAT protein