Rabbit LCOR Polyclonal Antibody | anti-LCOR antibody

LCOR Rabbit Polyclonal

Cat. Num. AAA7600963

• Gene Names: LCOR; MLR2
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: LCOR; Polyclonal Antibody; LCOR Rabbit Polyclonal; anti-LCOR antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 406

• Applicable Applications for anti-LCOR antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Ligand dependent nuclear receptor corepressor
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human endometrial cancer using MBS7600963 (LCOR antibody) at dilution of 1:50)

Western Blot (WB)

(HeLa cells were subjected to SDS PAGE followed by western blot with MBS7600963 (LCOR antibody) at dilution of 1:300)

NCBI and Uniprot Product Information

• NCBI GI #: 282847506
• NCBI GeneID: 84458
• NCBI Accession #: NP_001164237.1
• NCBI GenBank Nucleotide #: NM_001170766.1
• Molecular Weight: 44,083 Da
• NCBI Official Full Name: ligand-dependent corepressor isoform 2
• NCBI Official Synonym Full Names: ligand dependent nuclear receptor corepressor
• NCBI Official Symbol: LCOR
• NCBI Official Synonym Symbols: MLR2
• NCBI Protein Information: ligand-dependent corepressor
• UniProt Protein Name: Ligand-dependent corepressor
• Protein Family: Ligand-dependent corepressor
• UniProt Gene Name: LCOR
• UniProt Synonym Gene Names: KIAA1795; MLR2; LCoR
• UniProt Entry Name: LCOR_HUMAN

NCBI Description

LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (Fernandes et al., 2003 [PubMed 12535528]).[supplied by OMIM, Mar 2008]

Uniprot Description

LCOR: May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand- dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: nucleus

Molecular Function: DNA binding; protein binding; transcription factor activity; transcription factor binding

Biological Process: negative regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter