Rabbit LCA5 Polyclonal Antibody | anti-LCA5 antibody

Anti-LCA5 Antibody

Cat. Num. AAA415694

• Gene Names: LCA5; C6orf152
• Reactivity: Human. Predicted: Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity purified
• Synonyms: LCA5; Polyclonal Antibody; Anti-LCA5 Antibody; anti-LCA5 antibody

• Host: Rabbit
• Reactivity: Human. Predicted: Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Affinity purified
• Form/Format: Liquid
• Concentration: 100ug/100ul (varies by lot)
• Sequence Length: 4733

• Applicable Applications for anti-LCA5 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: ELISA titer: 1:20,000-1:80,000; Western blot analysis: 1:1,000-1:2,000; Immunohistochemistry: 1:100-1:500; Optimal dilutions/concentrations should be determined by the end user.
• Storage Buffer: PBS, pH 7.4 with 0.02% Sodium Azide
• Immunogen: Rabbit polyclonal LCA5 (1) antibody was raised against a recombinated human LCA5 protein 37-222aa (BC050327).
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Testing Data

Related Product Information for anti-LCA5 antibody

This gene encodes a protein that is thought to be involved in centrosomal or ciliary functions. Mutations in this gene cause Leber congenital amaurosis type V. Alternatively spliced transcript variants are described. [provided by RefSeq, Oct 2009]

References

(1) Ahmad,A., Daud,S., Kakar,N., et al. Identification of a novel LCA5 mutation in a Pakistani family with Leber congenital amaurosis and cataracts. Mol. Vis. 17, 1940-1945 (2011).

NCBI and Uniprot Product Information

• NCBI GI #: 30046696
• NCBI GeneID: 167691
• Molecular Weight: 80,554 Da
• NCBI Official Full Name: Homo sapiens Leber congenital amaurosis 5, mRNA
• NCBI Official Synonym Full Names: Leber congenital amaurosis 5
• NCBI Official Symbol: LCA5
• NCBI Official Synonym Symbols: C6orf152
• NCBI Protein Information: Lebercilin; leber congenital amaurosis 5 protein
• UniProt Protein Name: Lebercilin
• Protein Family: Lebercilin
• UniProt Gene Name: LCA5
• UniProt Entry Name: LCA5_HUMAN

NCBI Description

This gene encodes a protein that is thought to be involved in centrosomal or ciliary functions. Mutations in this gene cause Leber congenital amaurosis type V. Alternatively spliced transcript variants are described. [provided by RefSeq, Oct 2009]

Uniprot Description

LCA5: Might be involved in minus end-directed microtubule transport. Defects in LCA5 are the cause of Leber congenital amaurosis type 5 (LCA5). LCA designates a clinically and genetically heterogeneous group of childhood retinal degenerations, generally inherited in an autosomal recessive manner. Affected infants have little or no retinal photoreceptor function as tested by electroretinography. LCA represents the most common genetic cause of congenital visual impairment in infants and children. Belongs to the LCA5 family.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 6q14.1

Cellular Component: cytoplasm; microtubule organizing center; cilium

Molecular Function: protein binding; protein complex binding

Biological Process: protein transport; photoreceptor cell maintenance; intraflagellar transport

Disease: Leber Congenital Amaurosis 5