Western Blot (WB)
(Western blot analysis of LAT2 expression in HEK293T (A), HepG2 (B), mouse kidney (C), rat brain (D) whole cell lysates.)
Rabbit LAT2 Polyclonal Antibody | anti-SLC7A8 antibody
Anti-LAT2 Antibody
Western Blot (WB)
(Western blot analysis of LAT2 expression in HEK293T (A), HepG2 (B), mouse kidney (C), rat brain (D) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of LAT2 expression in HEK293T (A), HepG2 (B), mouse kidney (C), rat brain (D) whole cell lysates.)
NCBI and Uniprot Product Information
Uniprot Description
SLC7A8: Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney. Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
Protein type: Membrane protein, integral; Transporter, SLC family; Transporter; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component: basolateral plasma membrane; integral to plasma membrane; cytoplasm; plasma membrane
Molecular Function: L-amino acid transmembrane transporter activity; protein binding; peptide antigen binding; neutral amino acid transmembrane transporter activity; toxin transporter activity; organic cation transmembrane transporter activity; amino acid transmembrane transporter activity
Biological Process: neutral amino acid transport; amino acid metabolic process; metal ion homeostasis; organic cation transport; transport; amino acid transport; response to toxin; ion transport; blood coagulation; leukocyte migration; transmembrane transport
Research Articles on SLC7A8
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Product Notes
The SLC7A8 slc7a8 (Catalog #AAA8213654) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-LAT2 Antibody reacts with Human, Mouse, Rat, Rabbit and may cross-react with other species as described in the data sheet. AAA Biotech's LAT2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB (1/500 - 1/1000). Researchers should empirically determine the suitability of the SLC7A8 slc7a8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LAT2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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