Rabbit anti-Human LAMA4 Polyclonal Antibody | anti-LAMA4 antibody

LAMA4 Rabbit Polyclonal

Cat. Num. AAA7600910

• Gene Names: LAMA4; LAMA3; CMD1JJ; LAMA4*-1
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: LAMA4; Polyclonal Antibody; LAMA4 Rabbit Polyclonal; anti-LAMA4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 120

• Applicable Applications for anti-LAMA4 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Laminin, alpha 4
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human ovary using MBS7600910 (LAMA4 antibody) at dilution of 1:100)

Western Blot (WB)

(human heart tissue were subjected to SDS PAGE followed by western blot with MBS7600910 (LAMA4 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 157419130
• NCBI GeneID: 3910
• NCBI Accession #: NP_001098679.1
• NCBI GenBank Nucleotide #: NM_001105209.2
• Molecular Weight: 12,819 Da
• NCBI Official Full Name: laminin subunit alpha-4 isoform 3
• NCBI Official Synonym Full Names: laminin subunit alpha 4
• NCBI Official Symbol: LAMA4
• NCBI Official Synonym Symbols: LAMA3; CMD1JJ; LAMA4*-1
• NCBI Protein Information: laminin subunit alpha-4
• UniProt Protein Name: Laminin subunit alpha-4
• Protein Family: Laminin
• UniProt Gene Name: LAMA4
• UniProt Entry Name: LAMA4_HUMAN

NCBI Description

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the alpha chain isoform laminin, alpha 4. The domain structure of alpha 4 is similar to that of alpha 3, both of which resemble truncated versions of alpha 1 and alpha 2, in that approximately 1,200 residues at the N-terminus (domains IV, V and VI) have been lost. Laminin, alpha 4 contains the C-terminal G domain which distinguishes all alpha chains from the beta and gamma chains. The RNA analysis from adult and fetal tissues revealed developmental regulation of expression, however, the exact function of laminin, alpha 4 is not known. Tissue-specific utilization of alternative polyA-signal has been described in literature. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]

Uniprot Description

LAMA4: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis; Extracellular matrix

Chromosomal Location of Human Ortholog: 6q21

Cellular Component: basal lamina; basement membrane; extracellular matrix; extracellular region

Molecular Function: extracellular matrix structural constituent; protein binding; receptor binding

Biological Process: cell adhesion; extracellular matrix organization and biogenesis; regulation of cell adhesion; regulation of cell migration; regulation of embryonic development

Disease: Cardiomyopathy, Dilated, 1jj