Goat anti-Monkey lactoferrin Polyclonal Antibody | anti-LTF antibody

Goat anti Monkey lactoferrin, conjugated with FITC

Cat. Num. AAA573134

• Gene Names: LTF; LF; HLF2; GIG12
• Reactivity: Monkey
• Applications: ELISA, Immunocytochemistry, Immunohistochemistry, Immunohistochemistry, Immunofluorescence
• Synonyms: lactoferrin; Polyclonal Antibody; Goat anti Monkey lactoferrin; conjugated with FITC; anti-LTF antibody

• Host: Goat
• Reactivity: Monkey
• Clonality: Polyclonal
• Specificity: Fluorescein isothiocyanate-conjugated IgG fraction of polyclonal Goat antiSerum to Monkey lactoferrin.

• Applicable Applications for anti-LTF antibody: ELISA (EIA), Immunocytochemistry (IHC), Immunohistochemistry (IHC), (In)direct Immunofluorescence (IF)
• Conjugation: FITC
• Reactivity Note: The antiSerum does not cross-react with any other Monkey plasma proteins as tested in gel-diffusion techniques. Inter-species cross-reactivity is a normal feature of antibodies to plasma or milk proteins, since homologous proteins of different species frequently share antigenic determinants. Cross-reactivity of this antiSerum has not been tested in detail, however a strong cross-reaction with lactoferrin in Human milk has been observed.
• Preparation and Storage: Store at 4 degree C.

Product Categories/Family for anti-LTF antibody

Conjugated Secondary Antibody

NCBI and Uniprot Product Information

• NCBI GI #: 2104522
• NCBI GeneID: 4057
• UniProt Accession #: P02788; O00756; Q16780; Q16785; Q16786; Q16789; Q5DSM0; Q8IU92; Q8IZH6; B2MV13; B7Z4X2; E7EQH5
• Molecular Weight: 78,182 Da
• NCBI Official Full Name: lactoferrin
• NCBI Official Synonym Full Names: lactotransferrin
• NCBI Official Symbol: LTF
• NCBI Official Synonym Symbols: LF; HLF2; GIG12
• NCBI Protein Information: lactotransferrin; talalactoferrin; neutrophil lactoferrin; growth-inhibiting protein 12
• UniProt Protein Name: Lactotransferrin
• Protein Family: Lactotransferrin
• UniProt Gene Name: LTF
• UniProt Synonym Gene Names: GIG12; LF; Lactoferrin; Lfcin-H
• UniProt Entry Name: TRFL_HUMAN

NCBI Description

This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Uniprot Description

LTF: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Belongs to the transferrin family. 2 isoforms of the human protein are produced by alternative promoter.

Protein type: Protease; Secreted; Secreted, signal peptide; EC 3.4.21.-

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: extracellular space; specific granule; cytoplasm; extracellular region; nucleus; secretory granule

Molecular Function: heparin binding; protein serine/threonine kinase activator activity; protein binding; DNA binding; ferric iron binding; iron ion binding; serine-type endopeptidase activity

Biological Process: interaction with host; negative regulation of lipopolysaccharide-mediated signaling pathway; ossification; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; positive regulation of toll-like receptor 4 signaling pathway; antifungal humoral response; proteolysis; iron ion transport; humoral immune response; regulation of cytokine production; activation of NF-kappaB transcription factor; retinal homeostasis; positive regulation of osteoblast differentiation; innate immune response in mucosa; negative regulation of viral genome replication; response to host immune response; positive regulation of osteoblast proliferation; antibacterial humoral response; regulation of tumor necrosis factor production; negative regulation of ATPase activity; negative regulation of viral reproduction; iron assimilation by chelation and transport; negative regulation of apoptosis