Rabbit Kv7.3/KCNQ3 Polyclonal Antibody | anti-Kv7.3/KCNQ3 antibody

Kv7.3/KCNQ3 Antibody

Cat. Num. AAA9503969

• Gene Names: KCNQ3; EBN2; BFNC2; KV7.3
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, ELISA
• Purity: Purified from rabbit antiserum by affinity-chromatography using immunogen.
• Synonyms: Kv7.3/KCNQ3; Polyclonal Antibody; Kv7.3/KCNQ3 Antibody; anti-Kv7.3/KCNQ3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: Kv7.3/KCNQ3 Antibody detects endogenous levels of total Kv7.3/KCNQ3 protein.
• Purity/Purification: Purified from rabbit antiserum by affinity-chromatography using immunogen.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 752

• Applicable Applications for anti-Kv7.3/KCNQ3 antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:50~1:100; ELISA: 1:1000
• Target Modification: Unmodified/Total
• Immunogen: The antiserum was produced against synthesized peptide derived from human Kv7.3/KCNQ3.
• Immunogen Range: 191-240
• Preparation and Storage: Stable at -20 degree C for at least 1 year.

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Kv7.3/KCNQ3 Antibody. The picture on the right is blocked with the synthesized peptide.)

NCBI and Uniprot Product Information

• NCBI GI #: 325651930
• NCBI GeneID: 3786
• NCBI Accession #: NP_001191753.1
• NCBI GenBank Nucleotide #: NM_001204824.1
• UniProt Accession #: O43525; A2VCT8; B4DJY4; E7EQ89
• Molecular Weight: 96 kDa
• NCBI Official Full Name: potassium voltage-gated channel subfamily KQT member 3 isoform 2
• NCBI Official Synonym Full Names: potassium voltage-gated channel subfamily Q member 3
• NCBI Official Symbol: KCNQ3
• NCBI Official Synonym Symbols: EBN2; BFNC2; KV7.3
• NCBI Protein Information: potassium voltage-gated channel subfamily KQT member 3
• UniProt Protein Name: Potassium voltage-gated channel subfamily KQT member 3
• UniProt Gene Name: KCNQ3

NCBI Description

This gene encodes a protein that functions in the regulation of neuronal excitability. The encoded protein forms an M-channel by associating with the products of the related KCNQ2 or KCNQ5 genes, which both encode integral membrane proteins. M-channel currents are inhibited by M1 muscarinic acetylcholine receptors and are activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2). Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]

Uniprot Description

Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability.