Rabbit anti-Human KTEL1 Polyclonal Antibody | anti-KTEL1 antibody

KTEL1, CT (POGLUT1, C3orf9, CLP46, KTELC1, MDSRP, Protein O-glucosyltransferase 1, CAP10-like 46kD protein, KTEL motif-containing protein 1, Myelodysplastic syndromes relative protein) (PE)

Cat. Num. AAA6314974

• Gene Names: POGLUT1; Rumi; CLP46; MDSRP; C3orf9; KTELC1; LGMD2Z; MDS010; hCLP46; KDELCL1
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: KTEL1; Polyclonal Antibody; CT (POGLUT1; C3orf9; CLP46; KTELC1; MDSRP; Protein O-glucosyltransferase 1; CAP10-like 46kD protein; KTEL motif-containing protein 1; Myelodysplastic syndromes relative protein) (PE); POGLUT1; Myelodysplastic syndromes relative protein; anti-KTEL1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-KTEL1 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: KTEL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 360~390 amino acids from the C-terminal region of human KTEL1.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western blot analysis of KTEL1 Antibody (C-term) in T47D cell line lysates (35ug/lane). KTEL1 (arrow) was detected using the purified Pab.)

Product Categories/Family for anti-KTEL1 antibody

Antibodies; KIAA; orf

References

Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010). Karadonta, A.V., et al. Int J Immunopathol Pharmacol 22(3):787-793(2009). Teng, Y., et al. Gene 371(1):7-15(2006). Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003).

NCBI and Uniprot Product Information

• NCBI GI #: 31982953
• NCBI GeneID: 56983
• NCBI Accession #: NP_689518.1
• NCBI GenBank Nucleotide #: NM_152305.2
• UniProt Accession #: Q8NBL1; Q53GJ4; Q8N2T1; B2RD13
• Molecular Weight: 46,189 Da
• NCBI Official Full Name: protein O-glucosyltransferase 1
• NCBI Official Synonym Full Names: protein O-glucosyltransferase 1
• NCBI Official Symbol: POGLUT1
• NCBI Official Synonym Symbols: Rumi; CLP46; MDSRP; C3orf9; KTELC1; LGMD2Z; MDS010; hCLP46; KDELCL1
• NCBI Protein Information: protein O-glucosyltransferase 1
• UniProt Protein Name: Protein O-glucosyltransferase 1
• UniProt Gene Name: POGLUT1
• UniProt Synonym Gene Names: C3orf9; CLP46; KTELC1; MDSRP; hCLP46; hRumi

NCBI Description

This gene encodes a protein with both O-glucosyltransferase and O-xylosyltransferase activity which localizes to the lumen of the endoplasmic reticulum. This protein has a carboxy-terminal KTEL motif which is predicted to function as an endoplasmic reticulum retention signal. This gene is an essential regulator of Notch signalling and likely plays a role in cell fate and tissue formation during development. It may also play a role in the pathogenesis of leukemia. Mutations in this gene have been associated with the autosomal dominant genodermatosis Dowling-Degos disease 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Uniprot Description

KTELC1: UDP-glucosyltransferase. Belongs to the glycosyltransferase 90 family.

Protein type: EC 2.4.2.26; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3q13.33

Cellular Component: endoplasmic reticulum lumen

Molecular Function: glucosyltransferase activity; UDP-glucosyltransferase activity; UDP-xylosyltransferase activity

Biological Process: glycolipid metabolic process; positive regulation of Notch signaling pathway; protein amino acid O-linked glycosylation

Disease: Dowling-degos Disease 4; Muscular Dystrophy, Limb-girdle, Type 2z