Western Blot (WB)
(Western blot analysis of Kremen (arrow) using Kremen Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the Kremen gene (Lane 2) (Origene Technologies).)
Rabbit anti-Human Kremen Polyclonal Antibody | anti-KREMEN1 antibody
Kremen Antibody (N-term)
Western Blot (WB)
(Western blot analysis of Kremen (arrow) using Kremen Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the Kremen gene (Lane 2) (Origene Technologies).)
Western Blot (WB)
(Western blot analysis of Kremen (arrow) using Kremen Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the Kremen gene (Lane 2) (Origene Technologies).)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
Western Blot (WB)
(Kremen (DKK5) Antibody (R21) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the Kremen (DKK5) antibody detected the Kremen (DKK5) protein (arrow).)
Western Blot (WB)
(Kremen (DKK5) Antibody (R21) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the Kremen (DKK5) antibody detected the Kremen (DKK5) protein (arrow).)
Nakamura, T., et al., Biochim. Biophys. Acta 1518 (1-2), 63-72 (2001).
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
KREMEN1: Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 22q12.1
Cellular Component: membrane; integral to membrane
Molecular Function: protein binding
Biological Process: Wnt receptor signaling pathway; cell communication
Research Articles on KREMEN1
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Product Notes
The KREMEN1 kremen1 (Catalog #AAA9212746) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 6-37. The Kremen Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Kremen can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the KREMEN1 kremen1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Kremen, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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