Rabbit anti-Human KLRC3 Polyclonal Antibody | anti-KLRC3 antibody

Anti-KLRC3 Antibody, Rabbit Polyclonal

Cat. Num. AAA8102045

• Gene Names: KLRC3; NKG2E; NKG2-E
• Reactivity: Human
• Applications: Western Blot
• Purity: Protein A & Antigen Affinity
• Synonyms: KLRC3; Polyclonal Antibody; Anti-KLRC3 Antibody; Rabbit Polyclonal; KLRC3/NKG2E Antibody; Rabbit PAb; Antigen Affinity Purified; killer cell lectin like receptor C3; Anti-NKG2-E Antibody; Anti-NKG2E Antibody; anti-KLRC3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human KLRC3/NKG2E
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-KLRC3 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to the N-terminus of the Human KLRC3/NKG2E
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the Human KLRC3/NKG2E, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Western Blot (WB)

(Anti-KLRC3 rabbit polyclonal antibody at 1:500 dilutionLane A: Jurkat Whole Cell LysateLysates/proteins at 30 ug per lane.SecondaryGoat Anti- Rabbit  IgG H&L (Dylight 800)  at 1/10000 dilution.Developed using the Odyssey technique. Performed under reducing conditions.Predicted band size:27 kDaObserved band size:22 kDa)

Related Product Information for anti-KLRC3 antibody

KLRC3 (Killer Cell Lectin Like Receptor C3) is a Protein Coding gene. KLRC3 is a member of the NKG2 group which is expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. Expression of KLRC3 in type 1 diabetes mellitus (T1DM) might play a role in the pathogenesis of T1DM and could be a predictor of its severity.KLRC3 silencing decreased self-renewal capacity, invasion, proliferation, radioresistance, and tumourigenicity of U87-MG glioblastoma cell line.KLRC3 gene expression is linked to glioblastoma aggressiveness and could be a new potential therapeutic target to attenuate glioblastoma.

NCBI and Uniprot Product Information

• NCBI GI #: 75709175
• NCBI GeneID: 3823
• NCBI Accession #: NP_002252.2
• NCBI GenBank Nucleotide #: NM_002261.2
• UniProt Accession #: Q07444; Q8WXA4; Q96RL0; Q9UP04
• Molecular Weight: 29,018 Da
• NCBI Official Full Name: NKG2-E type II integral membrane protein isoform E
• NCBI Official Synonym Full Names: killer cell lectin-like receptor subfamily C, member 3
• NCBI Official Symbol: KLRC3
• NCBI Official Synonym Symbols: NKG2E; NKG2-E
• NCBI Protein Information: NKG2-E type II integral membrane protein; NK cell receptor E; NKG2-E-activating NK receptor
• UniProt Protein Name: NKG2-E type II integral membrane protein
• Protein Family: NKG2-E type II integral membrane protein
• UniProt Gene Name: KLRC3
• UniProt Synonym Gene Names: NKG2E
• UniProt Entry Name: NKG2E_HUMAN

NCBI Description

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC3 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

KLRC3: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: integral to membrane

Molecular Function: transmembrane receptor activity; carbohydrate binding

Biological Process: cellular defense response; signal transduction