Western Blot (WB)
(Western Blot analysis of KLHL7 expression in transfected 293T cell line by KLHL7 polyclonal antibody. Lane 1: KLHL7 transfected lysate (64.46kD). Lane 2: Non-transfected lysate.)
Mouse anti-Human KLHL7 Polyclonal Antibody | anti-KLHL7 antibody
KLHL7 (Kelch-like Protein 7, KLHL6, RP42, SBBI26)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Western Blot (WB)
(Western Blot analysis of KLHL7 expression in transfected 293T cell line by KLHL7 polyclonal antibody. Lane 1: KLHL7 transfected lysate (64.46kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of KLHL7 expression in transfected 293T cell line by KLHL7 polyclonal antibody. Lane 1: KLHL7 transfected lysate (64.46kD). Lane 2: Non-transfected lysate.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a BTB-Kelch-related protein. The encoded protein may be involved in protein degradation. Mutations in this gene have been associated with retinitis pigmentosa 42. [provided by RefSeq, Feb 2010]
Uniprot Description
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination. Ref.10
Pathway: Protein modification; protein ubiquitination.
Subunit structure: Homodimer. Component of the BCR(KLHL7) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL7 and RBX1. Ref.10
Subcellular location: Nucleus Ref.9.
Tissue specificity: Widely expressed, with highest levels in adult and fetal heart, CNS and adult testis. Ref.9
Involvement in disease: Retinitis pigmentosa 42 (RP42) [MIM:612943]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10 Ref.12 Ref.13 Ref.14
Sequence similarities: Contains 1 BACK (BTB/Kelch associated) domain.Contains 1 BTB (POZ) domain.Contains 6 Kelch repeats.
Research Articles on KLHL7
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Product Notes
The KLHL7 klhl7 (Catalog #AAA647354) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The KLHL7 (Kelch-like Protein 7, KLHL6, RP42, SBBI26) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's KLHL7 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Researchers should empirically determine the suitability of the KLHL7 klhl7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MAASGVEKSS KKKTEKKLAA REEAKLLAGF MGVMNNMRKQ KTLCDVILMV QERKIPAHRV VLAAASHFFN LMFTTNMLES KSFELELKDA EPDIIEQLVE FAYTARISVN SNNVQSLLDA ANQYQIEPVK KMCVDFLKEQ VDASNCLGIS VLAECLDCPE LKATADDFIH QHFTEVYKTD EFLQLDVKRV THLLNQDTLT VRAEDQVYDA AVRWLKYDEP NRQPFMVDIL AKVRFPLISK NFLSKTVQAE PLIQDNPECL KMVISGMRYH LLSPEDREEL VDGTRPRRKK HDYRIALFGG SQPQSCRYFN PKDYSWTDIR CPFEKRRDAA CVFWDNVVYI LGGSQLFPIK RMDCYNVVKD SWYSKLGPPT PRDSLAACAA EGKIYTSGGS EVGNSALYLF ECYDTRTESW HTKPSMLTQR CSHGMVEANG LIYVCGGSLG NNVSGRVLNS CEVYDPATET WTELCPMIEA RKNHGLVFVK DKIFAVGGQN GLGGLDNVEY YDIKLNEWKM VSPMPWKGVT VKCAAVGSIV YVLAGFQGVG RLGHILEYNT ETDKWVANSK VRAFPVTSCL ICVVDTCGAN EETLET. It is sometimes possible for the material contained within the vial of "KLHL7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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