Rabbit KIF5A Polyclonal Antibody | anti-KIF5A antibody

KIF5A (Kinesin Family Member 5A, NKHC, MY050, SPG10, D12S1889) (FITC)

Cat. Num. AAA6423859

• Gene Names: KIF5A; NKHC; MY050; SPG10; D12S1889
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by affinity chromatography.
• Synonyms: KIF5A; Polyclonal Antibody; KIF5A (Kinesin Family Member 5A; NKHC; MY050; SPG10; D12S1889) (FITC); anti-KIF5A antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes KIF5A. Species Crossreactivity: human, mouse, rat
• Purity/Purification: Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
• Concentration: ~1mg/ml (varies by lot)

• Applicable Applications for anti-KIF5A antibody: Immunohistochemistry (IHC), Western Blot (WB)
• Application Notes: IHC: 1:50-1:200; WB: 1:1000-1:2000; Applications are based on unconjugated antibody.
• Immunogen: Recombinant protein corresponding to human KIF5A.
• Conjugate: FITC
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Product Categories/Family for anti-KIF5A antibody

Antibodies; Motor Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 45446749
• NCBI GeneID: 3798
• NCBI Accession #: NP_004975.2
• NCBI GenBank Nucleotide #: NM_004984.2
• UniProt Accession #: Q12840; Q4LE26; A6H8M5
• Molecular Weight: 117,378 Da
• NCBI Official Full Name: kinesin heavy chain isoform 5A
• NCBI Official Synonym Full Names: kinesin family member 5A
• NCBI Official Symbol: KIF5A
• NCBI Official Synonym Symbols: NKHC; MY050; SPG10; D12S1889
• NCBI Protein Information: kinesin heavy chain isoform 5A; KIF5A variant protein; neuronal kinesin heavy chain; kinesin heavy chain neuron-specific 1; kinesin, heavy chain, neuron-specific
• UniProt Protein Name: Kinesin heavy chain isoform 5A
• Protein Family: Kinesin
• UniProt Gene Name: KIF5A
• UniProt Synonym Gene Names: NKHC1; NKHC
• UniProt Entry Name: KIF5A_HUMAN

NCBI Description

This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal dominant spastic paraplegia 10. [provided by RefSeq, Jul 2008]

Uniprot Description

KIF5A: Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Defects in KIF5A are the cause of spastic paraplegia autosomal dominant type 10 (SPG10). An inherited degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity (stiffness) of the legs. Rate of progression and the severity of symptoms is quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Belongs to the kinesin-like protein family. Kinesin subfamily.

Protein type: Motor; Microtubule-binding

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: kinesin complex; microtubule; membrane; perinuclear region of cytoplasm; cytosol

Molecular Function: protein binding; plus-end-directed microtubule motor activity; microtubule binding; ATPase activity; motor activity; ATP binding

Biological Process: axon guidance; synaptic transmission; protein localization; metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class II; cytoskeleton-dependent intracellular transport; blood coagulation; microtubule-based movement

Disease: Spastic Paraplegia 10, Autosomal Dominant