Rabbit anti-Human KCNS3 Polyclonal Antibody | anti-KCNS3 antibody

KCNS3, NT (KCNS3, Potassium voltage-gated channel subfamily S member 3, Delayed-rectifier K(+) channel alpha subunit 3, Voltage-gated potassium channel subunit Kv9.3) (AP)

Cat. Num. AAA6312753

• Gene Names: KCNS3; KV9.3
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: KCNS3; Polyclonal Antibody; NT (KCNS3; Potassium voltage-gated channel subfamily S member 3; Delayed-rectifier K(+) channel alpha subunit 3; Voltage-gated potassium channel subunit Kv9.3) (AP); Voltage-gated potassium channel subunit Kv9.3; anti-KCNS3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
• Sequence Length: 491

• Applicable Applications for anti-KCNS3 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: KCNS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human KCNS3.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(KCNS3 Antibody (N-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the KCNS3 antibody detected the KCNS3 protein (arrow).)

Product Categories/Family for anti-KCNS3 antibody

Antibodies; Ion Channel

References

Nyholt, D.R., et al. Hum. Mol. Genet. 17(21):3318-3331(2008). van Es, M.A., et al. Nat. Genet. 40(1):29-31(2008). Schymick, J.C., et al. Lancet Neurol 6(4):322-328(2007). Gutman, G.A., et al. Pharmacol. Rev. 57(4):473-508(2005). Kerschensteiner, D., et al. Proc. Natl. Acad. Sci. U.S.A. 102(17):6160-6165(2005).

NCBI and Uniprot Product Information

• NCBI GI #: 25952108
• NCBI GeneID: 3790
• NCBI Accession #: NP_002243.3
• NCBI GenBank Nucleotide #: NP_002243.3
• UniProt Accession #: Q9BQ31
• NCBI Official Full Name: potassium voltage-gated channel subfamily S member 3
• NCBI Official Synonym Full Names: potassium voltage-gated channel modifier subfamily S member 3
• NCBI Official Symbol: KCNS3
• NCBI Official Synonym Symbols: KV9.3
• NCBI Protein Information: potassium voltage-gated channel subfamily S member 3
• UniProt Protein Name: Potassium voltage-gated channel subfamily S member 3
• Protein Family: Potassium voltage-gated channel subfamily
• UniProt Gene Name: KCNS3

NCBI Description

Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]

Uniprot Description

Kv9.3: Potassium channel subunit. Modulates channel activity and reduces the ion flow. Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.3/KCNS3 sub-subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2p24.2

Cellular Component: cytosol; Golgi apparatus; integral component of membrane; plasma membrane; voltage-gated potassium channel complex

Molecular Function: delayed rectifier potassium channel activity; potassium channel regulator activity

Biological Process: potassium ion transport; protein homooligomerization; regulation of insulin secretion; regulation of molecular function