Rabbit anti-Human KCNJ15 Polyclonal Antibody | anti-KCNJ15 antibody

KCNJ15, CT (KCNJ15, KCNJ14, ATP-sensitive inward rectifier potassium channel 15, Inward rectifier K(+) channel Kir1.3, Inward rectifier K(+) channel Kir4.2, Potassium channel, inwardly rectifying subfamily J member 15) (MaxLight 490)

Cat. Num. AAA6312550

• Gene Names: KCNJ15; IRKK; KIR1.3; KIR4.2
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: KCNJ15; Polyclonal Antibody; CT (KCNJ15; KCNJ14; ATP-sensitive inward rectifier potassium channel 15; Inward rectifier K(+) channel Kir1.3; Inward rectifier K(+) channel Kir4.2; Potassium channel; inwardly rectifying subfamily J member 15) (MaxLight 490); inwardly rectifying subfamily J member 15; anti-KCNJ15 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human KCNJ15.
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.
• Sequence Length: 375

• Applicable Applications for anti-KCNJ15 antibody: Western Blot (WB), FLISA
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 339-367 in the C-terminal region of human KCNJ15, UniProt Accession #Q99712.
• Conjugate: MaxLight490
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in MDA-MB231 cell line lysates (35ug/lane) usingMBS645874. This demonstrates that MBS645874 detected the KCNJ15 protein (arrow).)

Related Product Information for anti-KCNJ15 antibody

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Three transcript variants encoding the same protein have been found for this gene.

Product Categories/Family for anti-KCNJ15 antibody

Antibodies; Ion Channel

References

1. Okamoto, K., et al. Am. J. Hum. Genet. 86(1):54-64(2010). 2. Sindic, A., et al. Am. J. Physiol. Renal Physiol. 297 (1), F36-F45 (2009). 3. Ji, W., et al. Nat. Genet. 40(5):592-599(2008). 4. Huang, C., et al. Am. J. Physiol. Renal Physiol. 292 (3), F1073-F1081 (2007). 5. Kubo, Y., et al. Pharmacol. Rev. 57(4):509-526(2005).

NCBI and Uniprot Product Information

• NCBI GI #: 25777638
• NCBI GeneID: 3772
• NCBI Accession #: NP_733932.1; NP_002234.2
• NCBI GenBank Nucleotide #: NP_733932.1
• UniProt Accession #: Q99712
• NCBI Official Full Name: ATP-sensitive inward rectifier potassium channel 15
• NCBI Official Synonym Full Names: potassium inwardly rectifying channel subfamily J member 15
• NCBI Official Symbol: KCNJ15
• NCBI Official Synonym Symbols: IRKK; KIR1.3; KIR4.2
• NCBI Protein Information: ATP-sensitive inward rectifier potassium channel 15
• UniProt Protein Name: ATP-sensitive inward rectifier potassium channel 15
• Protein Family: ATP-sensitive inward rectifier potassium channel
• UniProt Gene Name: KCNJ15
• UniProt Synonym Gene Names: KCNJ14

NCBI Description

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2013]

Uniprot Description

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.