Dilution Information
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Rabbit Kappa Polyclonal Antibody
Kappa/FITC, Rpab
Applications
Immunohistochemistry
Synonyms
Kappa; Polyclonal Antibody; Kappa/FITC; Rpab; anti-Kappa antibody
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Form/Format
Concentrate or Prediluted
Sequence Length
107
Applicable Applications for anti-Kappa antibody
Immunohistochemistry (IHC) Frozen/Paraffin
Immunogen
Purified Kappa Light Chains from human myeloma serum.
Localization
Cytoplasmic
Control
Tonsil, Lymph Node
Preparation and Storage
Store at 2-8 degree C in the dark.
Dilution Information
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Dilution Information
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Immunofluorescence (IF)
(IF of Kappa on a FFPE Tonsil Tissue)
Immunofluorescence (IF)
(IF of Kappa on a FFPE Tonsil Tissue)
Related Product Information for anti-Kappa antibody
Kappa detects surface immunoglobulin on normal and neoplastic B-cells. In paraffinembedded tissue, Kappa exhibits strong staining of kappa-positive plasma cells and cells that have absorbed exogenous immunoglobulin.
When studying B-cell neoplasms, the determination of light-chain ratios remains the centerpiece. This is sound reasoning because most B-cell Lymphomas express either Kappa or Lambda light chains, whereas reactive proliferations display a mixture of Kappa and Lambda-positive cells. If only a single light-chain type is detected, a lympho-proliferative disorder is very likely. Monoclonality is determined by a Kappa-Lambda ratio greater than or equal to 3:1, a Lambda-Kappa ratio greater than or equal to 2:1, or a monoclonal population of 75% or more of the total population. In IgG-dominant immune complex-mediated glomerulonephritis, there are multiple pathological findings that strongly suggest the identification of Lupus Nephritis including immunofluorescence staining for IgG, IgM, IgA, Kappa or Lambda, C3 and C1.
When studying B-cell neoplasms, the determination of light-chain ratios remains the centerpiece. This is sound reasoning because most B-cell Lymphomas express either Kappa or Lambda light chains, whereas reactive proliferations display a mixture of Kappa and Lambda-positive cells. If only a single light-chain type is detected, a lympho-proliferative disorder is very likely. Monoclonality is determined by a Kappa-Lambda ratio greater than or equal to 3:1, a Lambda-Kappa ratio greater than or equal to 2:1, or a monoclonal population of 75% or more of the total population. In IgG-dominant immune complex-mediated glomerulonephritis, there are multiple pathological findings that strongly suggest the identification of Lupus Nephritis including immunofluorescence staining for IgG, IgM, IgA, Kappa or Lambda, C3 and C1.
Product Categories/Family for anti-Kappa antibody
NCBI and Uniprot Product Information
Similar Products
Product Notes
The Kappa (Catalog #AAA370403) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Kappa can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Frozen/Paraffin. Researchers should empirically determine the suitability of the Kappa for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Kappa, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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