Western Blot (WB)
(JUNB Antibody (Center) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the JUNB antibody detected the JUNB protein (arrow).)
Rabbit anti-Human JUNB Polyclonal Antibody | anti-RNASEH2A antibody
JUNB, ID (JUNB, Transcription factor jun-B)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Western Blot (WB)
(JUNB Antibody (Center) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the JUNB antibody detected the JUNB protein (arrow).)
Western Blot (WB)
(JUNB Antibody (Center) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the JUNB antibody detected the JUNB protein (arrow).)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.[provided by RefSeq, Aug 2009]
Uniprot Description
RNASEH2A: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. Defects in RNASEH2A are the cause of Aicardi-Goutieres syndrome type 4 (AGS4). A form of Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infection. Clinical features as thrombocytopenia, hepatosplenomegaly and elevated hepatic transaminases along with intermittent fever may erroneously suggest an infective process. Severe neurological dysfunctions manifest in infancy as progressive microcephaly, spasticity, dystonic posturing and profound psychomotor retardation. Death often occurs in early childhood. Belongs to the RNase HII family. Eukaryotic subfamily.
Protein type: EC 3.1.26.4; Ribonuclease; DNA replication
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: nucleus
Molecular Function: RNA binding; metal ion binding; ribonuclease H activity; ribonuclease activity
Biological Process: mismatch repair; RNA catabolic process; DNA replication
Disease: Aicardi-goutieres Syndrome 4
Research Articles on RNASEH2A
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Product Notes
The RNASEH2A junb (Catalog #AAA6009491) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The JUNB, ID (JUNB, Transcription factor jun-B) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's JUNB can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in Western Blot, ELISA Dilution: ELISA: 1:1,000 Western Blot: 1:100-500. Researchers should empirically determine the suitability of the RNASEH2A junb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "JUNB, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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