Western Blot (WB)
(Western blot analysis of TAOK3 (arrow) using rabbit polyclonal TAOK3 Antibody (C-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the TAOK3 gene (Lane 2) (Origene Technologies).)
Rabbit JIK (TAOK3) Polyclonal Antibody | anti-TAOK3 antibody
JIK (TAOK3) Antibody (C-term)
Western Blot (WB)
(Western blot analysis of TAOK3 (arrow) using rabbit polyclonal TAOK3 Antibody (C-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the TAOK3 gene (Lane 2) (Origene Technologies).)
Western Blot (WB)
(Western blot analysis of TAOK3 (arrow) using rabbit polyclonal TAOK3 Antibody (C-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the TAOK3 gene (Lane 2) (Origene Technologies).)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with TAOK3 antibody (C-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with TAOK3 antibody (C-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Yustein,J.T.,Oncogene 22 (40), 6129-6141 (2003)
Yoneda,T.,J. Biol. Chem. 276 (17), 13935-13940 (2001)
Zhang,W.,Biochem. Biophys. Res. Commun. 274 (3), 872-879 (2000)
NCBI and Uniprot Product Information
Uniprot Description
TAO3: Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress- activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF). Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, STE; EC 2.7.11.1; STE group; STE20 family; TAO subfamily
Chromosomal Location of Human Ortholog: 12q
Cellular Component: cytoplasm; plasma membrane
Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; protein kinase inhibitor activity; MAP kinase kinase kinase activity; ATP binding
Biological Process: negative regulation of JNK cascade; positive regulation of JNK activity; activation of MAPKK activity; protein amino acid autophosphorylation; mitotic cell cycle G2/M transition DNA damage checkpoint; MAPKKK cascade; positive regulation of JNK cascade; negative regulation of protein kinase activity; DNA repair; response to DNA damage stimulus; protein amino acid phosphorylation; positive regulation of stress-activated MAPK cascade
Research Articles on TAOK3
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Product Notes
The TAOK3 taok3 (Catalog #AAA9214011) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 671-700. The JIK (TAOK3) Antibody (C-term) reacts with Human (Predicted Reactivity: Chicken, Mouse, Rat, Xenopus) and may cross-react with other species as described in the data sheet. AAA Biotech's JIK (TAOK3) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the TAOK3 taok3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "JIK (TAOK3), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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