Goat anti-Human JAM2 Polyclonal Antibody | anti-JAM2 antibody

JAM2 (Junctional Adhesion Molecule B, JAM-B, Junctional Adhesion Molecule 2, JAM-2, Vascular Endothelial Junction-associated Molecule, VE-JAM, CD322, C21orf43, VEJAM, UNQ219/PRO245)

Cat. Num. AAA648899

• Gene Names: JAM2; JAMB; CD322; JAM-B; VEJAM; PRO245; VE-JAM; C21orf43
• Reactivity: Human
• Applications: ELISA
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: JAM2; Polyclonal Antibody; JAM2 (Junctional Adhesion Molecule B; JAM-B; Junctional Adhesion Molecule 2; JAM-2; Vascular Endothelial Junction-associated Molecule; VE-JAM; CD322; C21orf43; VEJAM; UNQ219/PRO245); Anti -JAM2 (Junctional Adhesion Molecule B; anti-JAM2 antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes JAM2. Species sequence homology: Human.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

• Applicable Applications for anti-JAM2 antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.; Dilution: ELISA: 1:16,000
• Immunogen: Synthetic peptide corresponding to C-NPRLGSQSTNSSYT, from JAM2, at the internal region of the protein (NP_067042.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-JAM2 antibody

May play a role in the processes of lymphocyte homing to secondary lymphoid organs.

Product Categories/Family for anti-JAM2 antibody

Antibodies; Abs to Connexin; Junction Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 393715113
• NCBI GeneID: 58494
• NCBI Accession #: NP_001257337.1
• NCBI GenBank Nucleotide #: NM_001270408.1
• UniProt Accession #: P57087; Q6UXG6; Q6YNC1; B2R6T9; B4DGT9
• Molecular Weight: 33,207 Da
• NCBI Official Full Name: junctional adhesion molecule B isoform 3
• NCBI Official Synonym Full Names: junctional adhesion molecule 2
• NCBI Official Symbol: JAM2
• NCBI Official Synonym Symbols: JAMB; CD322; JAM-B; VEJAM; PRO245; VE-JAM; C21orf43
• NCBI Protein Information: junctional adhesion molecule B; JAM-2; JAM-IT/VE-JAM; vascular endothelial junction-associated molecule
• UniProt Protein Name: Junctional adhesion molecule B
• Protein Family: Junctional adhesion molecule
• UniProt Gene Name: JAM2
• UniProt Synonym Gene Names: C21orf43; VEJAM; JAM-B; JAM-2; VE-JAM
• UniProt Entry Name: JAM2_HUMAN

NCBI Description

This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012]

Uniprot Description

Function: May play a role in the processes of lymphocyte homing to secondary lymphoid organs.

Subunit structure: Interacts with JAM3. Ref.9

Subcellular location: Cell junction › tight junction

By similarity. Cell membrane; Single-pass type I membrane protein

By similarity. Note: Localized at tight junctions of both epithelial and endothelial cells

By similarity.

Tissue specificity: Highest expression in the heart, placenta, lung, foreskin and lymph node. Prominently expressed on high endothelial venules, also present on the endothelia of other vessels. Localized to the intercellular boundaries of high endothelial cells. Ref.1

Sequence similarities: Belongs to the immunoglobulin superfamily.Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 1 Ig-like V-type (immunoglobulin-like) domain.