Western Blot (WB)
(Western Blot analysis of 293T cells using JAK3 Polyclonal Antibody at dilution of 1:1000.)
Rabbit JAK3 Polyclonal Antibody | anti-JAK3 antibody
JAK3 Polyclonal Antibody
Western Blot (WB)
(Western Blot analysis of 293T cells using JAK3 Polyclonal Antibody at dilution of 1:1000.)
Western Blot (WB)
(Western Blot analysis of 293T cells using JAK3 Polyclonal Antibody at dilution of 1:1000.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human stomach tissue using JAK3 Polyclonal Antibody at dilution of 1:200.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human stomach tissue using JAK3 Polyclonal Antibody at dilution of 1:200.)
Immunofluorescence (IF)
(Immunofluorescence analysis of Rat kidney tissue using JAK3 Polyclonal Antibody at dilution of 1:200.)
Immunofluorescence (IF)
(Immunofluorescence analysis of Rat kidney tissue using JAK3 Polyclonal Antibody at dilution of 1:200.)
NCBI and Uniprot Product Information
Observed MW: 125
NCBI Description
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008]
Uniprot Description
JAK3: a non-receptor tyrosine-kinase of the Jak family expressed predominantly in immune cells. Mediates signal transduction via the common gamma-chain of cytokine receptors, including IL-2, -4, -7, -9, and -15. Interacts with members of the STAT (signal transduction and activators of transcription) family. Interacts with STAM2 and SHB. Contains two protein kinase domains. Mutations that abrogate JAK3 function cause an autosomal SCID (severe combined immunodeficiency disease). Inhibitor: R017s for organ transplants. Three differentially spliced isoforms have been described.
Protein type: EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; JakA family
Chromosomal Location of Human Ortholog: 19p13.1
Cellular Component: cytoskeleton; cytosol; endomembrane system; extrinsic to internal side of plasma membrane
Molecular Function: ATP binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein phosphatase binding; protein-tyrosine kinase activity; receptor binding
Biological Process: activation of MAPKK activity; adaptive immune response; axon guidance; B cell differentiation; cell migration; elevation of cytosolic calcium ion concentration; enzyme linked receptor protein signaling pathway; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; negative regulation of dendritic cell cytokine production; negative regulation of FasL biosynthetic process; negative regulation of interleukin-10 production; negative regulation of interleukin-12 production; negative regulation of T cell activation; negative regulation of T-helper 1 cell differentiation; nerve growth factor receptor signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of activated T cell proliferation; positive regulation of calcium ion transport; positive regulation of immune response; positive regulation of T cell proliferation; protein amino acid phosphorylation; Ras protein signal transduction; small GTPase mediated signal transduction; STAT protein nuclear translocation; T cell homeostasis; tyrosine phosphorylation of STAT protein; tyrosine phosphorylation of Stat5 protein; vascular endothelial growth factor receptor signaling pathway
Disease: Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-negative, B Cell-positive, Nk Cell-negative
Research Articles on JAK3
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Product Notes
The JAK3 jak3 (Catalog #AAA2536906) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The JAK3 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's JAK3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA). WB: 1:500-1:2000, IHC: 1:50-1:200, IF: 1:50-1:100, ELISA: 1:5000-1:20000. Researchers should empirically determine the suitability of the JAK3 jak3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "JAK3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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