Rabbit ITGB4 Polyclonal Antibody | anti-ITGB4 antibody

ITGB4 Antibody

Cat. Num. AAA9430785

• Gene Names: ITGB4; CD104; GP150
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: ITGB4; Polyclonal Antibody; ITGB4 Antibody; CD104; GP150; anti-ITGB4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: The antibody detects endogenous levels of total ITGB4 protein.
• Purity/Purification: Antigen affinity purification
• Form/Format: pH 7.4 PBS, 0.05% NaN3, 40% Glycerol
• Concentration: 0.7 mg/mL (varies by lot)
• Sequence Length: 1822

• Applicable Applications for anti-ITGB4 antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:20-100
• Immunogen: Synthetic peptide of human ITGB4
• Immunogen Type: Peptide
• Preparation and Storage: Store at -20 degree C.

Immunohistochemistry (IHC)

(The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 47804(ITGB4 Antibody) at dilution 1/25.(Original magnification: 200))

Immunohistochemistry (IHC)

(The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using 47804(ITGB4 Antibody) at dilution 1/25.(Original magnification: 200))

Related Product Information for anti-ITGB4 antibody

Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Product Categories/Family for anti-ITGB4 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 54607035
• NCBI GeneID: 3691
• NCBI Accession #: NP_000204.3
• NCBI GenBank Nucleotide #: NM_000213.5
• UniProt Accession #: P16144; O14690; O14691; O15339; O15340; O15341; Q0VF97; Q9UIQ4; A0AVL6
• Molecular Weight: 195,013 Da
• NCBI Official Full Name: integrin beta-4 isoform 1
• NCBI Official Synonym Full Names: integrin subunit beta 4
• NCBI Official Symbol: ITGB4
• NCBI Official Synonym Symbols: CD104; GP150
• NCBI Protein Information: integrin beta-4
• UniProt Protein Name: Integrin beta-4
• Protein Family: Integrin
• UniProt Gene Name: ITGB4

NCBI Description

Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464).