Rabbit anti-Human ITGAX Polyclonal Antibody | anti-ITGAX antibody

ITGAX polyclonal antibody

Cat. Num. AAA3007334

• Gene Names: ITGAX; CD11C; SLEB6
• Reactivity: Human
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: ITGAX; Polyclonal Antibody; ITGAX polyclonal antibody; Integrin alpha-X; CD11 antigen-like family member C; Leu M5; Leukocyte adhesion glycoprotein p150; 95 alpha chain; Leukocyte adhesion receptor p150; 95; CD11c; CD11C; anti-ITGAX antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: ITGAX polyclonal antibody detects endogenous levels of ITGAX protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
• Sequence Length: 1163

• Applicable Applications for anti-ITGAX antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: Synthetic peptide, corresponding to Human ITGAX.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of ITGAX polyclonal antibody at 1:500 dilutionLane1:U-87MG whole cell lysate (40ug) Lane2:A549 whole cell lysate (40ug) Lane3:Myla2059 whole cell lysate (40ug))

Related Product Information for anti-ITGAX antibody

CD11c (integrin alphaX, ITGAX) is a transmembrane glycoprotein that forms an alpha/beta heterodimer with CD18 (integrin beta2), which interacts with a variety of extracellular matrix molecules and cell surface proteins. CD11c is primarily used as a dendritic cell marker. Dendritic cells can be classified into two major types: CD11c+ conventional dendritic cells that specialize in antigen presentation, and CD11c- plasmacytoid dendritic cells that specialize in type I interferon production. CD11c expression has also been observed on activated NK cells, subsets of B cells, monocytes, granulocytes, and some B cell malignancies including hairy cell leukemia.

NCBI and Uniprot Product Information

• NCBI GI #: 34452173
• NCBI GeneID: 3687
• NCBI Accession #: NP_000878.2
• NCBI GenBank Nucleotide #: NP_000878.2
• UniProt Accession #: P20702
• Molecular Weight: ~ 145kDa
• NCBI Official Full Name: integrin alpha-X isoform 2
• NCBI Official Synonym Full Names: integrin subunit alpha X
• NCBI Official Symbol: ITGAX
• NCBI Official Synonym Symbols: CD11C; SLEB6
• NCBI Protein Information: integrin alpha-X
• UniProt Protein Name: Integrin alpha-X
• Protein Family: Integrin
• UniProt Gene Name: ITGAX
• UniProt Synonym Gene Names: CD11C
• UniProt Entry Name: ITAX_HUMAN

NCBI Description

This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]