Western Blot (WB)
(ITGA7 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the ITGA7 antibody detected the ITGA7 protein (arrow).)
Rabbit ITGA7 Polyclonal Antibody | anti-ITGA7 antibody
ITGA7 Antibody (N-term)
Western Blot (WB)
(ITGA7 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the ITGA7 antibody detected the ITGA7 protein (arrow).)
Western Blot (WB)
(ITGA7 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the ITGA7 antibody detected the ITGA7 protein (arrow).)
alpha chain family. Integrins are heterodimeric integral membrane
proteins composed of an alpha chain and a beta chain. They mediate
a wide spectrum of cell-cell and cell-matrix interactions, and thus
play a role in cell migration, morphologic development,
differentiation, and metastasis. This protein functions as a
receptor for the basement membrane protein laminin-1. It is mainly
expressed in skeletal and cardiac muscles and may be involved in
differentiation and migration processes during myogenesis. Defects
in this gene are associated with congenital myopathy. Alternatively
spliced transcript variants encoding different isoforms have been
noted for this gene.
Han, Y.C., et al. Cancer Res. 70(11):4375-4384(2010)
Rooney, J.E., et al. Proc. Natl. Acad. Sci. U.S.A. 106(19):7991-7996(2009)
Liu, J., et al. J. Biol. Chem. 283(51):35668-35678(2008)
Tran, T., et al. Am. J. Respir. Cell Mol. Biol. 37(6):668-680(2007)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. They mediate a wide spectrum of cell-cell and cell-matrix interactions, and thus play a role in cell migration, morphologic development, differentiation, and metastasis. This protein functions as a receptor for the basement membrane protein laminin-1. It is mainly expressed in skeletal and cardiac muscles and may be involved in differentiation and migration processes during myogenesis. Defects in this gene are associated with congenital myopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2009]
Uniprot Description
ITGA7: Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation. Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. Defects in ITGA7 are the cause of muscular dystrophy congenital due to integrin alpha-7 deficiency (MDCI). A form of congenital muscular dystrophy. Patients present at birth, or within the first few months of life, with hypotonia, muscle weakness and often with joint contractures. Belongs to the integrin alpha chain family. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion
Chromosomal Location of Human Ortholog: 12q13
Cellular Component: muscle tendon junction; cell surface; cytoplasm; plasma membrane; neuromuscular junction; sarcolemma
Molecular Function: integrin binding; protein heterodimerization activity; metal ion binding; laminin binding
Biological Process: integrin-mediated signaling pathway; regulation of cell shape; heterotypic cell-cell adhesion; skeletal muscle development; cell migration; extracellular matrix organization and biogenesis; muscle development; cell-matrix adhesion; blood vessel morphogenesis
Disease: Muscular Dystrophy, Congenital, Due To Integrin Alpha-7 Deficiency
Research Articles on ITGA7
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Product Notes
The ITGA7 itga7 (Catalog #AAA9213299) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 229-257. The ITGA7 Antibody (N-term) reacts with Human (Predicted Reactivity: Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's ITGA7 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the ITGA7 itga7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ITGA7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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