Rabbit ISG20 Polyclonal Antibody | anti-ISG20 antibody

ISG20 Rabbit Polyclonal

Cat. Num. AAA7600637

• Gene Names: ISG20; CD25; HEM45
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: ISG20; Polyclonal Antibody; ISG20 Rabbit Polyclonal; anti-ISG20 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 170

• Applicable Applications for anti-ISG20 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Interferon stimulated exonuclease gene 20kDa
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human colon tissue slide using MBS7600637 (ISG20 Antibody) at dilution of 1:50)

Western Blot (WB)

(Raji cells were subjected to SDS PAGE followed by western blot with MBS7600637 (ISG20 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 735367247
• NCBI GeneID: 3669
• NCBI Accession #: NP_001290164.1
• NCBI GenBank Nucleotide #: NM_001303235.1
• Molecular Weight: 9,199 Da
• NCBI Official Full Name: interferon-stimulated gene 20 kDa protein isoform b
• NCBI Official Synonym Full Names: interferon stimulated exonuclease gene 20
• NCBI Official Symbol: ISG20
• NCBI Official Synonym Symbols: CD25; HEM45
• NCBI Protein Information: interferon-stimulated gene 20 kDa protein
• UniProt Protein Name: Interferon-stimulated gene 20 kDa protein
• Protein Family: Interferon-stimulated gene 20 kDa protein
• UniProt Gene Name: ISG20
• UniProt Synonym Gene Names: HEM45
• UniProt Entry Name: ISG20_HUMAN

Uniprot Description

ISG20: Exonuclease with specificity for single-stranded RNA and, to a lesser extent for DNA. Degrades RNA at a rate that is approximately 35-fold higher than its rate for single-stranded DNA. Involved in the antiviral function of IFN against RNA viruses. Belongs to the exonuclease superfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ribonuclease; Nucleolus; Deoxyribonuclease; EC 3.1.13.1

Chromosomal Location of Human Ortholog: 15q26

Cellular Component: Cajal body; cytoplasm; nucleolus; nucleoplasm; nucleus; PML body

Molecular Function: 3'-5'-exoribonuclease activity; exonuclease activity; exoribonuclease II activity; metal ion binding; single-stranded DNA specific 3'-5' exodeoxyribonuclease activity; U1 snRNA binding; U2 snRNA binding

Biological Process: cell proliferation; defense response to virus; DNA catabolic process, exonucleolytic; negative regulation of viral genome replication; response to virus; RNA catabolic process; rRNA processing